Treatment with recombinant Sirt1 rewires the cardiac lipidome and rescues diabetes-related metabolic cardiomyopathy

BACKGROUND: Metabolic cardiomyopathy (MCM), characterized by intramyocardial lipid accumulation, drives the progression to heart failure with preserved ejection fraction (HFpEF). Although evidence suggests that the mammalian silent information regulator 1 (Sirt1) orchestrates myocardial lipid metabo...

Descripción completa

Detalles Bibliográficos
Autores principales: Costantino, Sarah, Mengozzi, Alessandro, Velagapudi, Srividya, Mohammed, Shafeeq Ahmed, Gorica, Era, Akhmedov, Alexander, Mongelli, Alessia, Pugliese, Nicola Riccardo, Masi, Stefano, Virdis, Agostino, Hülsmeier, Andreas, Matter, Christian Matthias, Hornemann, Thorsten, Melina, Giovanni, Ruschitzka, Frank, Luscher, Thomas Felix, Paneni, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10644415/
https://www.ncbi.nlm.nih.gov/pubmed/37957697
http://dx.doi.org/10.1186/s12933-023-02057-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10644415/
https://www.ncbi.nlm.nih.gov/pubmed/37957697
http://dx.doi.org/10.1186/s12933-023-02057-2

Ejemplares similares