Discovery and overproduction of novel highly bioactive pamamycins through transcriptional engineering of the biosynthetic gene cluster

BACKGROUND: Pamamycins are a family of highly bioactive macrodiolide polyketides produced by Streptomyces alboniger as a complex mixture of derivatives with molecular weights ranging from 579 to 705 Daltons. The large derivatives are produced as a minor fraction, which has prevented their isolation...

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Detalles Bibliográficos
Autores principales: Eckert, Nikolas, Rebets, Yuriy, Horbal, Lilya, Zapp, Josef, Herrmann, Jennifer, Busche, Tobias, Müller, Rolf, Kalinowski, Jörn, Luzhetskyy, Andriy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10644645/
https://www.ncbi.nlm.nih.gov/pubmed/37964282
http://dx.doi.org/10.1186/s12934-023-02231-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10644645/
https://www.ncbi.nlm.nih.gov/pubmed/37964282
http://dx.doi.org/10.1186/s12934-023-02231-x

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