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Discovery and overproduction of novel highly bioactive pamamycins through transcriptional engineering of the biosynthetic gene cluster

BACKGROUND: Pamamycins are a family of highly bioactive macrodiolide polyketides produced by Streptomyces alboniger as a complex mixture of derivatives with molecular weights ranging from 579 to 705 Daltons. The large derivatives are produced as a minor fraction, which has prevented their isolation...

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Detalles Bibliográficos
Autores principales:	Eckert, Nikolas, Rebets, Yuriy, Horbal, Lilya, Zapp, Josef, Herrmann, Jennifer, Busche, Tobias, Müller, Rolf, Kalinowski, Jörn, Luzhetskyy, Andriy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10644645/ https://www.ncbi.nlm.nih.gov/pubmed/37964282 http://dx.doi.org/10.1186/s12934-023-02231-x

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