Evidence of a synthetic lethality interaction between SETDB1 histone methyltransferase and CHD4 chromatin remodeling protein in a triple negative breast cancer cell line

During the tumorigenic process, cancer cells may become overly dependent on the activity of backup cellular pathways for their survival, representing vulnerabilities that could be exploited as therapeutic targets. Certain molecular vulnerabilities manifest as a synthetic lethality relationship, and...

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Detalles Bibliográficos
Autores principales: Moraes-Almeida, M.S., Sogayar, M.C., Demasi, M.A.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Divulgação Científica 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10644962/
https://www.ncbi.nlm.nih.gov/pubmed/37970920
http://dx.doi.org/10.1590/1414-431X2023e12854

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10644962/
https://www.ncbi.nlm.nih.gov/pubmed/37970920
http://dx.doi.org/10.1590/1414-431X2023e12854

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