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Insulin receptor Arg717 and IGF-1 receptor Arg704 play a key role in ligand binding and in receptor activation

The insulin receptor (IR, with its isoforms IR-A and IR-B) and the insulin-like growth factor 1 receptor (IGF-1R) are related tyrosine kinase receptors. Recently, the portfolio of solved hormone–receptor structures has grown extensively thanks to advancements in cryo-electron microscopy. However, th...

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Detalles Bibliográficos
Autores principales:	Kertisová, Anna, Žáková, Lenka, Macháčková, Kateřina, Marek, Aleš, Šácha, Pavel, Pompach, Petr, Jiráček, Jiří, Selicharová, Irena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645074/ https://www.ncbi.nlm.nih.gov/pubmed/37935358 http://dx.doi.org/10.1098/rsob.230142

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