Frequency of multiple changes to prespecified primary outcomes of clinical trials completed between 2009 and 2017 in German university medical centers: A meta-research study

BACKGROUND: Clinical trial registries allow assessment of deviations of published trials from their protocol, which may indicate a considerable risk of bias. However, since entries in many registries can be updated at any time, deviations may go unnoticed. We aimed to assess the frequency of changes...

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Detalles Bibliográficos
Autores principales: Holst, Martin, Haslberger, Martin, Yerunkar, Samruddhi, Strech, Daniel, Hemkens, Lars G., Carlisle, Benjamin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645365/
https://www.ncbi.nlm.nih.gov/pubmed/37906614
http://dx.doi.org/10.1371/journal.pmed.1004306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645365/
https://www.ncbi.nlm.nih.gov/pubmed/37906614
http://dx.doi.org/10.1371/journal.pmed.1004306

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