Reducing branched-chain amino acids improves cardiac stress response in mice by decreasing histone H3K23 propionylation

Identification of branched-chain amino acid (BCAA) oxidation enzymes in the nucleus led us to predict that they are a source of the propionyl-CoA that is utilized for histone propionylation and, thereby, regulate gene expression. To investigate the effects of BCAAs on the development of cardiac hype...

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Detalles Bibliográficos
Autores principales: Yang, Zhi, He, Minzhen, Austin, Julianne, Sayed, Danish, Abdellatif, Maha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645387/
https://www.ncbi.nlm.nih.gov/pubmed/37669116
http://dx.doi.org/10.1172/JCI169399

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645387/
https://www.ncbi.nlm.nih.gov/pubmed/37669116
http://dx.doi.org/10.1172/JCI169399

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