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Glucagon-like peptide-1 receptor blockade impairs islet secretion and glucose metabolism in humans
BACKGROUND: Proglucagon can be processed to glucagon-like peptide1 (GLP-1) within the islet, but its contribution to islet function in humans remains unknown. We sought to understand whether pancreatic GLP-1 alters islet function in humans and whether this is affected by type 2 diabetes. METHODS: We...
Main Authors: | , , , , , , , , , , |
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Format: | Online Article Text |
Language: | English |
Published: |
American Society for Clinical Investigation
2023
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Subjects: | |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645389/ https://www.ncbi.nlm.nih.gov/pubmed/37751301 http://dx.doi.org/10.1172/JCI173495 |