Glucagon-like peptide-1 receptor blockade impairs islet secretion and glucose metabolism in humans

BACKGROUND: Proglucagon can be processed to glucagon-like peptide1 (GLP-1) within the islet, but its contribution to islet function in humans remains unknown. We sought to understand whether pancreatic GLP-1 alters islet function in humans and whether this is affected by type 2 diabetes. METHODS: We...

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Detalles Bibliográficos
Autores principales: Welch, Andrew A., Farahani, Rahele A., Egan, Aoife M., Laurenti, Marcello C., Zeini, Maya, Vella, Max, Bailey, Kent R., Cobelli, Claudio, Dalla Man, Chiara, Matveyenko, Aleksey, Vella, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Clinical Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645389/
https://www.ncbi.nlm.nih.gov/pubmed/37751301
http://dx.doi.org/10.1172/JCI173495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645389/
https://www.ncbi.nlm.nih.gov/pubmed/37751301
http://dx.doi.org/10.1172/JCI173495

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