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Glucagon-like peptide-1 receptor blockade impairs islet secretion and glucose metabolism in humans
BACKGROUND: Proglucagon can be processed to glucagon-like peptide1 (GLP-1) within the islet, but its contribution to islet function in humans remains unknown. We sought to understand whether pancreatic GLP-1 alters islet function in humans and whether this is affected by type 2 diabetes. METHODS: We...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645389/ https://www.ncbi.nlm.nih.gov/pubmed/37751301 http://dx.doi.org/10.1172/JCI173495 |