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B-type Plexins promote the GTPase activity of Ran to affect androgen receptor nuclear translocation in prostate cancer
Resistance to anti-androgen therapy for metastatic prostate cancer is a major clinical problem. Sema3C promotes resistance to androgen withdrawal via its receptor, PlexinB1. Activation of PlexinB1 promotes the ligand-independent nuclear translocation of the androgen receptor (AR), which may contribu...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group US
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645588/ https://www.ncbi.nlm.nih.gov/pubmed/37563360 http://dx.doi.org/10.1038/s41417-023-00655-6 |