Improving the cytotoxic response of tumor-infiltrating lymphocytes towards advanced stage ovarian cancer with an oncolytic adenovirus expressing a human vIL-2 cytokine

While the presence of tumor-infiltrating lymphocytes (TILs) associates with improved survival prognosis in ovarian cancer (OvCa) patients, TIL therapy benefit is limited. Here, we evaluated an oncolytic adenovirus coding for a human variant IL-2 (vIL-2) cytokine, Ad5/3-E2F-d24-vIL2 (vIL-2 virus), al...

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Detalles Bibliográficos
Autores principales: Quixabeira, D. C. A., Jirovec, E., Pakola, S., Havunen, R., Basnet, S., Santos, J. M., Kudling, T. V., Clubb, J. H. A., Haybout, L., Arias, V., Grönberg-Vähä-Koskela, S., Cervera-Carrascon, V., Pasanen, A., Anttila, M., Tapper, J., Kanerva, A., Hemminki, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645590/
https://www.ncbi.nlm.nih.gov/pubmed/37666898
http://dx.doi.org/10.1038/s41417-023-00658-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645590/
https://www.ncbi.nlm.nih.gov/pubmed/37666898
http://dx.doi.org/10.1038/s41417-023-00658-3

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