In planta expression of human polyQ-expanded huntingtin fragment reveals mechanisms to prevent disease-related protein aggregation

In humans, aggregation of polyglutamine repeat (polyQ) proteins causes disorders such as Huntington’s disease. Although plants express hundreds of polyQ-containing proteins, no pathologies arising from polyQ aggregation have been reported. To investigate this phenomenon, we expressed an aggregation-...

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Detalles Bibliográficos
Autores principales: Llamas, Ernesto, Koyuncu, Seda, Lee, Hyun Ju, Wehrmann, Markus, Gutierrez-Garcia, Ricardo, Dunken, Nick, Charura, Nyasha, Torres-Montilla, Salvador, Schlimgen, Elena, Mandel, Amrei M., Theile, Erik Boelen, Grossbach, Jan, Wagle, Prerana, Lackmann, Jan-Wilm, Schermer, Bernhard, Benzing, Thomas, Beyer, Andreas, Pulido, Pablo, Rodriguez-Concepcion, Manuel, Zuccaro, Alga, Vilchez, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645592/
https://www.ncbi.nlm.nih.gov/pubmed/37783816
http://dx.doi.org/10.1038/s43587-023-00502-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645592/
https://www.ncbi.nlm.nih.gov/pubmed/37783816
http://dx.doi.org/10.1038/s43587-023-00502-1

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