Characterizing the mutational burden, DNA methylation landscape, and proteome of germ cell tumor-related somatic-type malignancies to identify the tissue-of-origin, mechanisms of therapy resistance, and druggable targets

BACKGROUND: Germ cell tumors (GCT) might undergo transformation into a somatic-type malignancy (STM), resulting in a cell fate switch to tumors usually found in somatic tissues, such as rhabdomyosarcomas or adenocarcinomas. STM is associated with a poor prognosis, but the molecular and epigenetic me...

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Detalles Bibliográficos
Autores principales: Bremmer, Felix, Pongratanakul, Pailin, Skowron, Margaretha, Che, Yue, Richter, Annika, Küffer, Stefan, Reuter-Jessen, Kirsten, Bohnenberger, Hanibal, Pauls, Stella, Kresbach, Catena, Schüller, Ulrich, Stühler, Kai, Ströbel, Philipp, Albers, Peter, Nettersheim, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645790/
https://www.ncbi.nlm.nih.gov/pubmed/37726478
http://dx.doi.org/10.1038/s41416-023-02425-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645790/
https://www.ncbi.nlm.nih.gov/pubmed/37726478
http://dx.doi.org/10.1038/s41416-023-02425-5

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