Propagation of PrP(Sc) in mice reveals impact of aggregate composition on prion disease pathogenesis

Infectious prions consist of PrP(Sc), a misfolded, aggregation-prone isoform of the host’s prion protein. PrP(Sc) assemblies encode distinct biochemical and biological properties. They harbor a specific profile of PrP(Sc) species, from small oligomers to fibrils in different ratios, where the highes...

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Detalles Bibliográficos
Autores principales: Chang, Sheng Chun, Hannaoui, Samia, Arifin, Maria Immaculata, Huang, Yuan-Hung, Tang, Xinli, Wille, Holger, Gilch, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645910/
https://www.ncbi.nlm.nih.gov/pubmed/37964018
http://dx.doi.org/10.1038/s42003-023-05541-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645910/
https://www.ncbi.nlm.nih.gov/pubmed/37964018
http://dx.doi.org/10.1038/s42003-023-05541-3

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