Cargando…

Propagation of PrP(Sc) in mice reveals impact of aggregate composition on prion disease pathogenesis

Infectious prions consist of PrP(Sc), a misfolded, aggregation-prone isoform of the host’s prion protein. PrP(Sc) assemblies encode distinct biochemical and biological properties. They harbor a specific profile of PrP(Sc) species, from small oligomers to fibrils in different ratios, where the highes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chang, Sheng Chun, Hannaoui, Samia, Arifin, Maria Immaculata, Huang, Yuan-Hung, Tang, Xinli, Wille, Holger, Gilch, Sabine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645910/ https://www.ncbi.nlm.nih.gov/pubmed/37964018 http://dx.doi.org/10.1038/s42003-023-05541-3

Ejemplares similares

The Structure of PrP(Sc) Prions
por: Wille, Holger, et al.
Publicado: (2018)

Cervid Prion Protein Polymorphisms: Role in Chronic Wasting Disease Pathogenesis
por: Arifin, Maria Immaculata, et al.
Publicado: (2021)

Inhibition of cholesterol recycling impairs cellular PrP(Sc) propagation
por: Gilch, Sabine, et al.
Publicado: (2009)

The prion 2018 round tables (I): the structure of PrP(Sc)
por: Baskakov, Ilia V., et al.
Publicado: (2019)

Genetic modulation of CWD prion propagation in cervid PrP Drosophila
por: Thackray, Alana M., et al.
Publicado: (2023)

Peptide aptamer targeting Aβ–PrP–Fyn axis reduces Alzheimer’s disease pathologies in 5XFAD transgenic mouse model
por: Ali, Tahir, et al.
Publicado: (2023)

Transmission of cervid prions to humanized mice demonstrates the zoonotic potential of CWD
por: Hannaoui, Samia, et al.
Publicado: (2022)

Heterogeneity of Abnormal Prion Protein (PrP(Sc)) in Murine Scrapie Prions Determined by PrP(Sc)-Specific Monoclonal Antibodies
por: USHIKI-KAKU, Yuko, et al.
Publicado: (2013)

Infectivity-associated PrP(Sc) and disease duration-associated PrP(Sc) of mouse BSE prions
por: Miyazawa, Kohtaro, et al.
Publicado: (2015)

Mammalian prion propagation in PrP transgenic Drosophila
por: Thackray, Alana M, et al.
Publicado: (2018)

Cellulose ether treatment in vivo generates chronic wasting disease prions with reduced protease resistance and delayed disease progression
por: Hannaoui, Samia, et al.
Publicado: (2019)

Exploration of the Main Sites for the Transformation of Normal Prion Protein (PrP(C)) into Pathogenic Prion Protein (PrP(sc))
por: Liu, Xi-Lin, et al.
Publicado: (2017)

PrP(Sc) formation and clearance as determinants of prion tropism
por: Shikiya, Ronald A., et al.
Publicado: (2017)

Chronic wasting disease: Emerging prions and their potential risk
por: Hannaoui, Samia, et al.
Publicado: (2017)

New and distinct chronic wasting disease strains associated with cervid polymorphism at codon 116 of the Prnp gene
por: Hannaoui, Samia, et al.
Publicado: (2021)

Anti-Prion Drug mPPIg5 Inhibits PrP(C) Conversion to PrP(Sc)
por: McCarthy, James M., et al.
Publicado: (2013)

The Octarepeat Region of the Prion Protein Is Conformationally Altered in PrP(Sc)
por: Yam, Alice Y., et al.
Publicado: (2010)

PrP(Sc)-Specific Antibodies with the Ability to Immunodetect Prion Oligomers
por: Tayebi, Mourad, et al.
Publicado: (2011)

Inflammatory response of microglia to prions is controlled by sialylation of PrP(Sc)
por: Srivastava, Saurabh, et al.
Publicado: (2018)

Ovine recombinant PrP as an inhibitor of ruminant prion propagation in vitro
por: Workman, Rob G., et al.
Publicado: (2017)

Small Protease Sensitive Oligomers of PrP(Sc) in Distinct Human Prions Determine Conversion Rate of PrP(C)
por: Kim, Chae, et al.
Publicado: (2012)

Glimepiride Reduces the Expression of PrP(C), Prevents PrP(Sc) Formation and Protects against Prion Mediated Neurotoxicity
por: Bate, Clive, et al.
Publicado: (2009)

A Camelid Anti-PrP Antibody Abrogates PrP(Sc) Replication in Prion-Permissive Neuroblastoma Cell Lines
por: Jones, Daryl Rhys, et al.
Publicado: (2010)

Identifying critical sites of PrP(c)-PrP(Sc) interaction in prion-infected cells by dominant-negative inhibition
por: Taguchi, Yuzuru, et al.
Publicado: (2013)

Heterogeneity of the Abnormal Prion Protein (PrP(Sc)) of the Chandler Scrapie Strain
por: Kasai, Kazuo, et al.
Publicado: (2013)

Glial activation in prion diseases is selectively triggered by neuronal PrP(Sc)
por: Lakkaraju, Asvin K. K., et al.
Publicado: (2022)

Destabilizing polymorphism in cervid prion protein hydrophobic core determines prion conformation and conversion efficiency
por: Hannaoui, Samia, et al.
Publicado: (2017)

Interaction of Peptide Aptamers with Prion Protein Central Domain Promotes α-Cleavage of PrP(C)
por: Corda, Erica, et al.
Publicado: (2018)

Cholesterol Balance in Prion Diseases and Alzheimer’s Disease
por: Hannaoui, Samia, et al.
Publicado: (2014)

Analysis of Prion Strains by PrP(Sc) Profiling in Sporadic Creutzfeldt–Jakob Disease
por: Schoch, Gaby, et al.
Publicado: (2006)

PrP(Sc )spreading patterns in the brain of sheep linked to different prion types
por: Wemheuer, Wiebke M, et al.
Publicado: (2011)

Prion acute synaptotoxicity is largely driven by protease-resistant PrP(Sc) species
por: Foliaki, Simote Totauhelotu, et al.
Publicado: (2018)

PrP aggregation can be seeded by pre-formed recombinant PrP amyloid fibrils without the replication of infectious prions
por: Barron, Rona M., et al.
Publicado: (2016)

Accumulation of Pathological Prion Protein PrP(Sc) in the Skin of Animals with Experimental and Natural Scrapie
por: Thomzig, Achim, et al.
Publicado: (2007)

How do PrP(Sc) Prions Spread between Host Species, and within Hosts?
por: Mabbott, Neil A.
Publicado: (2017)

Prion protein amino acid sequence influences formation of authentic synthetic PrP(Sc)
por: Block, Alyssa J., et al.
Publicado: (2023)

The N-Terminal Sequence of Prion Protein Consists an Epitope Specific to the Abnormal Isoform of Prion Protein (PrP(Sc))
por: Masujin, Kentaro, et al.
Publicado: (2013)

Sialylation of Prion Protein Controls the Rate of Prion Amplification, the Cross-Species Barrier, the Ratio of PrP(Sc) Glycoform and Prion Infectivity
por: Katorcha, Elizaveta, et al.
Publicado: (2014)

PrP(ST), a Soluble, Protease Resistant and Truncated PrP Form Features in the Pathogenesis of a Genetic Prion Disease
por: Friedman-Levi, Yael, et al.
Publicado: (2013)

PK-sensitive PrP(Sc) Is Infectious and Shares Basic Structural Features with PK-resistant PrP(Sc)
por: Sajnani, Gustavo, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_b6pgkcqg3a7gs6frr8o5t2ju92