Targeted suppression of mTORC2 reduces seizures across models of epilepsy

Epilepsy is a neurological disorder that poses a major threat to public health. Hyperactivation of mTOR complex 1 (mTORC1) is believed to lead to abnormal network rhythmicity associated with epilepsy, and its inhibition is proposed to provide some therapeutic benefit. However, mTOR complex 2 (mTORC2...

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Detalles Bibliográficos
Autores principales: Okoh, James, Mays, Jacqunae, Bacq, Alexandre, Oses-Prieto, Juan A., Tyanova, Stefka, Chen, Chien-Ju, Imanbeyev, Khalel, Doladilhe, Marion, Zhou, Hongyi, Jafar-Nejad, Paymaan, Burlingame, Alma, Noebels, Jeffrey, Baulac, Stephanie, Costa-Mattioli, Mauro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645975/
https://www.ncbi.nlm.nih.gov/pubmed/37963879
http://dx.doi.org/10.1038/s41467-023-42922-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645975/
https://www.ncbi.nlm.nih.gov/pubmed/37963879
http://dx.doi.org/10.1038/s41467-023-42922-y

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