Cargando…

The EZH2-H3K27me3 axis modulates aberrant transcription and apoptosis in cyclophosphamide-induced ovarian granulosa cell injury

Chemotherapy-induced ovarian damage and infertility are significant concerns for women of childbearing age with cancer; however, the underlying mechanisms are still not fully understood. Our study has revealed a close association between epigenetic regulation and cyclophosphamide (CTX)-induced ovari...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Yingyan, Ai, Leilei, Zhang, Yingyi, Li, Xiang, Xu, Shiqian, Yang, Weijie, Jin, Jiamin, Ma, Yerong, Hu, Zhanhong, Zhang, Yinli, Rong, Yan, Zhang, Songying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646043/ https://www.ncbi.nlm.nih.gov/pubmed/37963880 http://dx.doi.org/10.1038/s41420-023-01705-6

Ejemplares similares

Cyclophosphamide Exposure Causes Long-Term Detrimental Effect of Oocytes Developmental Competence Through Affecting the Epigenetic Modification and Maternal Factors’ Transcription During Oocyte Growth
por: Yang, Weijie, et al.
Publicado: (2021)

Metformin inhibits testosterone-induced endoplasmic reticulum stress in ovarian granulosa cells via inactivation of p38 MAPK
por: Jin, Jiamin, et al.
Publicado: (2020)

Ovulatory signal-triggered chromatin remodeling in ovarian granulosa cells by HDAC2 phosphorylation activation-mediated histone deacetylation
por: Jin, Jiamin, et al.
Publicado: (2023)

Decreased Expression of EZH2 in Granulosa Cells Contributes to Endometriosis-Associated Infertility by Targeting IL-1R2
por: Lin, Xiang, et al.
Publicado: (2022)

ADAMTS1 and HSPG2 mRNA levels in cumulus cells are related to human oocyte quality and controlled ovarian hyperstimulation outcomes
por: Ma, Yerong, et al.
Publicado: (2020)

EZH2/H3K27Me3 and phosphorylated EZH2 predict chemotherapy response and prognosis in ovarian cancer
por: Sun, Si, et al.
Publicado: (2020)

MIR143 Inhibits Steroidogenesis and Induces Apoptosis Repressed by H3K27me3 in Granulosa Cells
por: Zhong, Yuyi, et al.
Publicado: (2020)

Astronauts Plasma-Derived Exosomes Induced Aberrant EZH2-Mediated H3K27me3 Epigenetic Regulation of the Vitamin D Receptor
por: Bisserier, Malik, et al.
Publicado: (2022)

EZH2-mediated H3K27me3 inhibits ACE2 expression
por: Li, Yuanyuan, et al.
Publicado: (2020)

HucMSC-EVs Facilitate In Vitro Development of Maternally Aged Preantral Follicles and Oocytes
por: Zhang, Ying-Yi, et al.
Publicado: (2023)

EZH2-mediated H3K27me3 is a predictive biomarker and therapeutic target in uveal melanoma
por: Hou, Chen, et al.
Publicado: (2022)

EZH2-Mediated H3K27me3 Targets Transcriptional Circuits of Neuronal Differentiation
por: Buontempo, Serena, et al.
Publicado: (2022)

Correction: Overactivated sonic hedgehog signaling aggravates intrauterine adhesion via inhibiting autophagy in endometrial stromal cells
por: Wei, Cheng, et al.
Publicado: (2020)

Overactivated sonic hedgehog signaling aggravates intrauterine adhesion via inhibiting autophagy in endometrial stromal cells
por: Wei, Cheng, et al.
Publicado: (2020)

Mutations in OOEP and NLRP5 identified in infertile patients with early embryonic arrest
por: Tong, Xiaomei, et al.
Publicado: (2022)

EZH2 dependent H3K27me3 is involved in epigenetic silencing of ID4 in prostate cancer
por: Chinaranagari, Swathi, et al.
Publicado: (2014)

Remarkable Synergy When Combining EZH2 Inhibitors with YM155 Is H3K27me3-Independent
por: Yang, Jun, et al.
Publicado: (2022)

EZH2-H3K27me3 mediated KRT14 upregulation promotes TNBC peritoneal metastasis
por: Verma, Ayushi, et al.
Publicado: (2022)

Novel WEE2 compound heterozygous mutations identified in patients with fertilization failure or poor fertilization
por: Jin, Jiamin, et al.
Publicado: (2021)

Androgens regulate ovarian gene expression by balancing Ezh2-Jmjd3 mediated H3K27me3 dynamics
por: Roy, Sambit, et al.
Publicado: (2021)

FBP1 knockdown decreases ovarian cancer formation and cisplatin resistance through EZH2-mediated H3K27me3
por: Xiong, Xifeng, et al.
Publicado: (2022)

Ezh2 mediated H3K27me3 activity facilitates somatic transition during human pluripotent reprogramming
por: Rao, Radhika Arasala, et al.
Publicado: (2015)

Inhibition of EZH2 Promotes Human Embryonic Stem Cell Differentiation into Mesoderm by Reducing H3K27me3
por: Yu, Yongxin, et al.
Publicado: (2018)

Inhibition of EZH2 Promotes Human Embryonic Stem Cell Differentiation into Mesoderm by Reducing H3K27me3
por: Yu, Yongxin, et al.
Publicado: (2017)

H3K27me3 and EZH2 expression in melanoma: relevance for melanoma progression and response to immune checkpoint blockade
por: Hoffmann, Friederike, et al.
Publicado: (2020)

Role of EZH2-mediated H3K27me3 in placental ADAM12-S expression: implications for fetoplacental growth
por: Zhu, Ya-nan, et al.
Publicado: (2022)

OR31-04 Androgen Signaling Regulates Female Fertility Through Modulation of H3K27me3 in Granulosa Cells
por: Roy, Sambit, et al.
Publicado: (2020)

LINC00114 stimulates growth and glycolysis of esophageal cancer cells by recruiting EZH2 to enhance H3K27me3 of DLC1
por: Qin, Jianzhang, et al.
Publicado: (2022)

Activation of Steroidogenesis, Anti-Apoptotic Activity, and Proliferation in Porcine Granulosa Cells by RUNX1 Is Negatively Regulated by H3K27me3 Transcriptional Repression
por: Zhong, Yuyi, et al.
Publicado: (2020)

EZH2-Mediated H3K27me3 Is Involved in Epigenetic Repression of Deleted in Liver Cancer 1 in Human Cancers
por: Au, Sandy Leung-Kuen, et al.
Publicado: (2013)

The EZH2–PRC2–H3K27me3 axis governs the endometrial cell cycle and differentiation for blastocyst invasion
por: Fukui, Yamato, et al.
Publicado: (2023)

Decreased histidine-rich glycoprotein and increased complement C4-B protein levels in follicular fluid predict the IVF outcomes of recurrent spontaneous abortion
por: Sun, Xiaohe, et al.
Publicado: (2022)

Correction: EZH2-Mediated H3K27me3 Is Involved in Epigenetic Repression of Deleted in Liver Cancer 1 in Human Cancers
por: Au, Sandy Leung-Kuen, et al.
Publicado: (2014)

Prognostic implications of polycomb proteins ezh2, suz12, and eed1 and histone modification by H3K27me3 in sarcoma
por: Cho, Yong Jin, et al.
Publicado: (2018)

Azithromycin attenuates wheezing after pulmonary inflammation through inhibiting histone H3K27me3 hypermethylation mediated by EZH2
por: Wu, Shuqi, et al.
Publicado: (2023)

EZH2-H3K27me3-mediated silencing of mir-139-5p inhibits cellular senescence in hepatocellular carcinoma by activating TOP2A
por: Wang, Ke, et al.
Publicado: (2023)

Quantification of Histone H3 Lys27 Trimethylation (H3K27me3) by High-Throughput Microscopy Enables Cellular Large-Scale Screening for Small-Molecule EZH2 Inhibitors
por: Luense, Svenja, et al.
Publicado: (2015)

Prognostic Value of Polycomb Proteins EZH2, BMI1 and SUZ12 and Histone Modification H3K27me3 in Colorectal Cancer
por: Benard, Anne, et al.
Publicado: (2014)

Aberrant Upregulation of 14-3-3σ and EZH2 Expression Serves as an Inferior Prognostic Biomarker for Hepatocellular Carcinoma
por: Zhang, Yi, et al.
Publicado: (2014)

Interplay of miR-137 and EZH2 contributes to the genome-wide redistribution of H3K27me3 underlying the Pb-induced memory impairment
por: Gu, Xiaozhen, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_asjc2587rc09qep8j5faka5ck0