An adaptive stress response that confers cellular resilience to decreased ubiquitination

Ubiquitination is a post-translational modification initiated by the E1 enzyme UBA1, which transfers ubiquitin to ~35 E2 ubiquitin-conjugating enzymes. While UBA1 loss is cell lethal, it remains unknown how partial reduction in UBA1 activity is endured. Here, we utilize deep-coverage mass spectromet...

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Detalles Bibliográficos
Autores principales: Hunt, Liam C., Pagala, Vishwajeeth, Stephan, Anna, Xie, Boer, Kodali, Kiran, Kavdia, Kanisha, Wang, Yong-Dong, Shirinifard, Abbas, Curley, Michelle, Graca, Flavia A., Fu, Yingxue, Poudel, Suresh, Li, Yuxin, Wang, Xusheng, Tan, Haiyan, Peng, Junmin, Demontis, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646096/
https://www.ncbi.nlm.nih.gov/pubmed/37963875
http://dx.doi.org/10.1038/s41467-023-43262-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646096/
https://www.ncbi.nlm.nih.gov/pubmed/37963875
http://dx.doi.org/10.1038/s41467-023-43262-7

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