Multi-omic profiling reveals discrepant immunogenic properties and a unique tumor microenvironment among melanoma brain metastases

Melanoma brain metastases (MBM) are clinically challenging to treat and exhibit variable responses to immune checkpoint therapies. Prior research suggests that MBM exhibit poor tumor immune responses and are enriched in oxidative phosphorylation. Here, we report results from a multi-omic analysis of...

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Detalles Bibliográficos
Autores principales: In, Gino K., Ribeiro, Jennifer R., Yin, Jun, Xiu, Joanne, Bustos, Matias A., Ito, Fumito, Chow, Frances, Zada, Gabriel, Hwang, Lindsay, Salama, April K. S., Park, Soo J., Moser, Justin C., Darabi, Sourat, Domingo-Musibay, Evidio, Ascierto, Maria L., Margolin, Kim, Lutzky, Jose, Gibney, Geoffrey T., Atkins, Michael B., Izar, Benjamin, Hoon, Dave S. B., VanderWalde, Ari M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646102/
https://www.ncbi.nlm.nih.gov/pubmed/37964004
http://dx.doi.org/10.1038/s41698-023-00471-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646102/
https://www.ncbi.nlm.nih.gov/pubmed/37964004
http://dx.doi.org/10.1038/s41698-023-00471-z

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