Cargando…

Multi-omic profiling reveals discrepant immunogenic properties and a unique tumor microenvironment among melanoma brain metastases

Melanoma brain metastases (MBM) are clinically challenging to treat and exhibit variable responses to immune checkpoint therapies. Prior research suggests that MBM exhibit poor tumor immune responses and are enriched in oxidative phosphorylation. Here, we report results from a multi-omic analysis of...

Descripción completa

Detalles Bibliográficos
Autores principales:	In, Gino K., Ribeiro, Jennifer R., Yin, Jun, Xiu, Joanne, Bustos, Matias A., Ito, Fumito, Chow, Frances, Zada, Gabriel, Hwang, Lindsay, Salama, April K. S., Park, Soo J., Moser, Justin C., Darabi, Sourat, Domingo-Musibay, Evidio, Ascierto, Maria L., Margolin, Kim, Lutzky, Jose, Gibney, Geoffrey T., Atkins, Michael B., Izar, Benjamin, Hoon, Dave S. B., VanderWalde, Ari M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646102/ https://www.ncbi.nlm.nih.gov/pubmed/37964004 http://dx.doi.org/10.1038/s41698-023-00471-z

Ejemplares similares

Personalized Medicine in Oncology; a Special Issue of the Journal of Personalized Medicine
por: VanderWalde, Ari
Publicado: (2021)

Comparison of Chemotherapy vs Chemotherapy Plus Total Hysterectomy for Women With Uterine Cancer With Distant Organ Metastasis
por: Wang, Yuefeng, et al.
Publicado: (2021)

Precision Medicine in Oncology: A Review of Multi-Tumor Actionable Molecular Targets with an Emphasis on Non-Small Cell Lung Cancer
por: Stein, Matthew K., et al.
Publicado: (2021)

Prospective Trial of Monocyte Count as a Biomarker of Hand-Foot Syndrome Among Patients With Soft Tissue Sarcomas Treated With Pegylated Liposomal Doxorubicin and Ifosfamide
por: Skubitz, Keith M, et al.
Publicado: (2022)

Prospective Trial of Neutrophil/Lymphocyte Ratio and Other Blood Counts as Biomarkers of Survival among Patients with High-Grade Soft Tissue Sarcomas Treated with Pegylated Liposomal Doxorubicin and Ifosfamide
por: Skubitz, Keith M., et al.
Publicado: (2022)

Developing an electronic geriatric assessment to improve care of older adults with cancer receiving radiotherapy
por: VanderWalde, Noam A., et al.
Publicado: (2020)

Establishment of a Molecular Tumor Board (MTB) and Uptake of Recommendations in a Community Setting
por: VanderWalde, Ari, et al.
Publicado: (2020)

Lymphadenopathy in COVID-19 Vaccine Recipients: Diagnostic Dilemma in Oncology Patients
por: Özütemiz, Can, et al.
Publicado: (2021)

Phase 1 results of a phase 1b/2, multicenter, open-label trial to evaluate safety and efficacy of talimogene laherparepvec (T-VEC) and ipilimumab (ipi) vs ipi alone in previously untreated, unresected stage IIIB-IV melanoma
por: Puzanov, Igor, et al.
Publicado: (2013)

Gene Expression and Mutational Profile in BAP-1 Inactivated Melanocytic Lesions of Progressive Malignancy from a Patient with Multiple Lesions
por: Zhou, Yan, et al.
Publicado: (2021)

Near complete response to Pembrolizumab in microsatellite-stable metastatic sebaceous carcinoma
por: Domingo-Musibay, Evidio, et al.
Publicado: (2018)

Transcriptional Profiling of Malignant Melanoma Reveals Novel and Potentially Targetable Gene Fusions
por: Darabi, Sourat, et al.
Publicado: (2022)

Endogenous Heat‐Shock Protein Induction with or Without Radiofrequency Ablation or Cryoablation in Patients with Stage IV Melanoma
por: Domingo‐Musibay, Evidio, et al.
Publicado: (2017)

Measles Edmonston Vaccine Strain Derivatives have Potent Oncolytic Activity against Osteosarcoma
por: Musibay, Evidio Domingo, et al.
Publicado: (2014)

Molecular profiling of melanoma brain metastases compared to primary cutaneous melanoma and to extracranial metastases
por: In, Gino K., et al.
Publicado: (2020)

Feasibility and Safety of Diffusing Alpha-Emitter Radiation Therapy for Recurrent or Unresectable Skin Cancers
por: D’Andrea, Mark A., et al.
Publicado: (2023)

Inhibition of the Aurora A kinase augments the anti-tumor efficacy of oncolytic measles virotherapy
por: Iankov, Ianko D., et al.
Publicado: (2015)

Programmatic Efforts Increase Adoption of Genomic Precision Medicine in Cancer Care in a Community Cancer Center
por: Darabi, Sourat, et al.
Publicado: (2022)

Conditional Survival and Cause-specific Mortality after Autologous Hematopoietic Cell Transplantation for Hematological Malignancies
por: VanderWalde, Ari M., et al.
Publicado: (2012)

Multiomic sequencing of paired primary and metastatic small bowel carcinoids
por: Postel, Mackenzie D., et al.
Publicado: (2023)

Microsatellite instability status determined by next‐generation sequencing and compared with PD‐L1 and tumor mutational burden in 11,348 patients
por: Vanderwalde, Ari, et al.
Publicado: (2018)

Geometric Discrepancy
por: Matousek, Jiri
Publicado: (1999)

Weathering the Storm: Managing Older Adults With Breast Cancer Amid COVID-19 and Beyond
por: Freedman, Rachel A, et al.
Publicado: (2020)

A Geriatric Assessment Intervention to Reduce Treatment Toxicity Among Older Adults With Advanced Lung Cancer: A Subgroup Analysis From a Cluster Randomized Controlled Trial
por: Presley, Carolyn J., et al.
Publicado: (2022)

Discrepant alterations in main candidate genes among multiple primary melanomas
por: Colombino, Maria, et al.
Publicado: (2014)

Lifileucel, a Tumor-Infiltrating Lymphocyte Therapy, in Metastatic Melanoma
por: Sarnaik, Amod A., et al.
Publicado: (2021)

Growth Deceleration for Limb Length Discrepancy: Tension Band Plates Followed to Maturity
por: Stevens, Peter, et al.
Publicado: (2022)

A Phase I/III, multicenter, open-label trial of talimogene laherparepvec (T-VEC) in combination with pembrolizumab for the treatment of unresected, stage IIIb-IV melanoma (MASTERKEY-265)
por: Long, Georgina V, et al.
Publicado: (2015)

Sequences, discrepancies and applications
por: Drmota, Michael, et al.
Publicado: (1997)

Discrepancies as to the Number of the Insured
Publicado: (1915)

On the Discrepancy of Medical Opinions
por: Woodham, James
Publicado: (1814)

A Discrepancy in the Transactions
Publicado: (1891)

Discrepancies Between Perceived Benefit of Opioids and Self-Reported Patient Outcomes
por: Goesling, Jenna, et al.
Publicado: (2018)

Children’s Mental Health: Discrepancy between Child Self-Reporting and Parental Reporting
por: Caqueo-Urízar, Alejandra, et al.
Publicado: (2022)

Association between Prior Malignancy Exclusion Criteria and Age Disparities in Cancer Clinical Trials
por: Patel, Roshal R., et al.
Publicado: (2022)

Leg length discrepancy ; The injured knee /
Publicado: (1977)

A panorama of discrepancy theory
por: Chen, William, et al.
Publicado: (2014)

The discrepancy method: randomness and complexity
por: Chazelle, Bernard
Publicado: (2000)

Private-Public Opinion Discrepancy
por: Manfredi, Ren, et al.
Publicado: (2020)

Patient recalls associated with resident-to-attending radiology report discrepancies: predictive factors for risky discrepancies
por: Son, A Yeon, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_fg7gq632hqdpo2prr038tsn510