Targeting regulatory T cells by E7777 enhances CD8 T-cell–mediated anti-tumor activity and extends survival benefit of anti-PD-1 in solid tumor models

INTRODUCTION: Regulatory T cell (Treg)-targeting cancer immunotherapy aims to transiently deplete Treg cells in the tumor microenvironment, without affecting effector T cells (Teff), thus both enhancing anti-tumor activity and avoiding autoimmunity. This study evaluated whether adding E7777 (a new f...

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Detalles Bibliográficos
Autores principales: Mahdi, Haider S., Woodall-Jappe, Mary, Singh, Preeti, Czuczman, Myron S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646188/
https://www.ncbi.nlm.nih.gov/pubmed/38022532
http://dx.doi.org/10.3389/fimmu.2023.1268979

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646188/
https://www.ncbi.nlm.nih.gov/pubmed/38022532
http://dx.doi.org/10.3389/fimmu.2023.1268979

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