Preferential Regulation of Γ‐Secretase‐Mediated Cleavage of APP by Ganglioside GM1 Reveals a Potential Therapeutic Target for Alzheimer's Disease

A hallmark of Alzheimer's disease (AD) is the senile plaque, which contains β‐amyloid peptides (Aβ). Ganglioside GM1 is the most common brain ganglioside. However, the mechanism of GM1 in modulating Aβ processing is rarely known. Aβ levels are detected by using Immunohistochemistry (IHC) and en...

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Detalles Bibliográficos
Autores principales: Wang, Xiaotong, Zhou, Rui, Sun, Xiaqin, Li, Jun, Wang, Jinxin, Yue, Weihua, Wang, Lifang, Liu, Hesheng, Shi, Yigong, Zhang, Dai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646247/
https://www.ncbi.nlm.nih.gov/pubmed/37759382
http://dx.doi.org/10.1002/advs.202303411

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646247/
https://www.ncbi.nlm.nih.gov/pubmed/37759382
http://dx.doi.org/10.1002/advs.202303411

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