Loss of ATOH1 in Pit Cell Drives Stemness and Progression of Gastric Adenocarcinoma by Activating AKT/mTOR Signaling through GAS1

Gastric cancer stem cells (GCSCs) are self‐renewing tumor cells that govern chemoresistance in gastric adenocarcinoma (GAC), whereas their regulatory mechanisms remain elusive. Here, the study aims to elucidate the role of ATOH1 in the maintenance of GCSCs. The preclinical model and GAC sample analy...

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Detalles Bibliográficos
Autores principales: Zhong, Qing, Wang, Hua‐Gen, Yang, Ji‐Hong, Tu, Ru‐Hong, Li, An‐Yao, Zeng, Gui‐Rong, Zheng, Qiao‐Ling, Yu Liu, Zhi‐, Shang‐Guan, Zhi‐Xin, Bo Huang, Xiao‐, Huang, Qiang, Li, Yi‐Fan, Zheng, Hua‐Long, Lin, Guang‐Tan, Huang, Ze‐Ning, Xu, Kai‐Xiang, Qiu, Wen‐Wu, Jiang, Mei‐Chen, Zhao, Ya‐Jun, Lin, Jian‐Xian, Huang, Zhi‐Hong, Huang, Jing‐Min, Li, Ping, Xie, Jian‐Wei, Zheng, Chao‐Hui, Chen, Qi‐Yue, Huang, Chang‐Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646280/
https://www.ncbi.nlm.nih.gov/pubmed/37824217
http://dx.doi.org/10.1002/advs.202301977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646280/
https://www.ncbi.nlm.nih.gov/pubmed/37824217
http://dx.doi.org/10.1002/advs.202301977

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