MYB insufficiency disrupts proteostasis in hematopoietic stem cells, leading to age-related neoplasia

MYB plays a key role in gene regulation throughout the hematopoietic hierarchy and is critical for the maintenance of normal hematopoietic stem cells (HSC). Acquired genetic dysregulation of MYB is involved in the etiology of a number of leukemias, although inherited noncoding variants of the MYB ge...

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Detalles Bibliográficos
Autores principales: Clarke, Mary L., Lemma, Roza B., Walton, David S., Volpe, Giacomo, Noyvert, Boris, Gabrielsen, Odd S., Frampton, Jon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Myeloid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646772/
https://www.ncbi.nlm.nih.gov/pubmed/36603185
http://dx.doi.org/10.1182/blood.2022019138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646772/
https://www.ncbi.nlm.nih.gov/pubmed/36603185
http://dx.doi.org/10.1182/blood.2022019138

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