Cargando…

Targeting biased signaling by PAR1: function and molecular mechanism of parmodulins

The G protein-coupled receptor (GPCR) protease-activated receptor 1 (PAR1) is a therapeutic target that was originally pursued with the aim of restricting platelet activation and the burden of cardiovascular diseases. In clinical studies, the use of orthosteric PAR1 inhibitors was associated with an...

Descripción completa

Detalles Bibliográficos
Autores principales: Künze, Georg, Isermann, Berend
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646804/
https://www.ncbi.nlm.nih.gov/pubmed/36952648
http://dx.doi.org/10.1182/blood.2023019775