Cargando…

Intranasal neuropeptide Y1 receptor antagonism improves motor deficits in symptomatic SOD1 ALS mice

OBJECTIVE: Neuropeptide Y (NPY) is a 36 amino acid peptide widely considered to provide neuroprotection in a range of neurodegenerative diseases. In the fatal motor neuron disease amyotrophic lateral sclerosis (ALS), recent evidence supports a link between NPY and ALS disease processes. The goal of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Clark, Rosemary M., Clark, Courtney M., Lewis, Katherine E.A., Dyer, Marcus S., Chuckowree, Jyoti A., Hoyle, Joshua A., Blizzard, Catherine A., Dickson, Tracey C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647012/ https://www.ncbi.nlm.nih.gov/pubmed/37644692 http://dx.doi.org/10.1002/acn3.51885

Ejemplares similares

Calretinin and Neuropeptide Y interneurons are differentially altered in the motor cortex of the SOD1(G93A) mouse model of ALS
por: Clark, Rosemary M., et al.
Publicado: (2017)

Differential NPY-Y1 Receptor Density in the Motor Cortex of ALS Patients and Familial Model of ALS
por: Clark, Courtney M., et al.
Publicado: (2021)

Efficacy of epothilones in central nervous system trauma treatment: what has age got to do with it?
por: Clark, Jayden, et al.
Publicado: (2020)

Estrogen Enhances Dendrite Spine Function and Recovers Deficits in Neuroplasticity in the prpTDP-43(A315T) Mouse Model of Amyotrophic Lateral Sclerosis
por: Handley, Emily E., et al.
Publicado: (2022)

A Case for Microtubule Vulnerability in Amyotrophic Lateral Sclerosis: Altered Dynamics During Disease
por: Clark, Jayden A., et al.
Publicado: (2016)

Epothilone D alters normal growth, viability and microtubule dependent intracellular functions of cortical neurons in vitro
por: Clark, J. A., et al.
Publicado: (2020)

The Microtubule-Modulating Drug Epothilone D Alters Dendritic Spine Morphology in a Mouse Model of Mild Traumatic Brain Injury
por: Chuckowree, Jyoti A., et al.
Publicado: (2018)

Reduced Excitability and Increased Neurite Complexity of Cortical Interneurons in a Familial Mouse Model of Amyotrophic Lateral Sclerosis
por: Clark, Rosemary M., et al.
Publicado: (2018)

Synaptic remodeling follows upper motor neuron hyperexcitability in a rodent model of TDP-43
por: Dyer, Marcus S., et al.
Publicado: (2023)

Amyotrophic lateral sclerosis mutant TDP-43 may cause synaptic dysfunction through altered dendritic spine function
por: Jiang, Tongcui, et al.
Publicado: (2019)

A Randomized Controlled Trial of Intranasal Neuropeptide Y in Patients With Major Depressive Disorder
por: Mathé, Aleksander A, et al.
Publicado: (2020)

Neuropeptide Y (NPY) intranasal delivery alleviates Machado–Joseph disease
por: Duarte-Neves, Joana, et al.
Publicado: (2021)

Neuropeptide Y1 receptor antagonism protects β-cells and improves glycemic control in type 2 diabetes
por: Yang, Chieh-Hsin, et al.
Publicado: (2021)

Intranasal Neuropeptide Y Blunts Lipopolysaccharide-Evoked Sickness Behavior but Not the Immune Response in Mice
por: Zenz, Geraldine, et al.
Publicado: (2019)

Identifying the primary site of pathogenesis in amyotrophic lateral sclerosis – vulnerability of lower motor neurons to proximal excitotoxicity
por: Blizzard, Catherine A., et al.
Publicado: (2015)

Adenosine A(2A) Receptors Activation Facilitates Neuromuscular Transmission in the Pre-Symptomatic Phase of the SOD1(G93A) ALS Mice, but Not in the Symptomatic Phase
por: Nascimento, Filipe, et al.
Publicado: (2014)

Anti-SOD1 Nanobodies That Stabilize Misfolded SOD1 Proteins Also Promote Neurite Outgrowth in Mutant SOD1 Human Neurons
por: Kumar, Meenakshi Sundaram, et al.
Publicado: (2022)

Inducing Chronic Excitotoxicity in the Mouse Spinal Cord to Investigate Lower Motor Neuron Degeneration
por: Blizzard, Catherine A., et al.
Publicado: (2016)

Molecular and pharmacological chaperones for SOD1
por: Wright, Gareth S.A.
Publicado: (2020)

Scolopendra subspinipes mutilans attenuates neuroinflammation in symptomatic hSOD1(G93A) mice
por: Cai, MuDan, et al.
Publicado: (2013)

Intranasal Delivery of Galanin 2 and Neuropeptide Y1 Agonists Enhanced Spatial Memory Performance and Neuronal Precursor Cells Proliferation in the Dorsal Hippocampus in Rats
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2022)

Reflex Effects of Intranasal Disease in the Pharynx and Mouth
por: Clark, Horace
Publicado: (1897)

Intranasal neuropeptide Y is most effective in some aspects of acute stress compared to melatonin, oxytocin and orexin
por: Zubkov, Eugene, et al.
Publicado: (2022)

Identification of Human Monoclonal Antibodies Specific for Human SOD1 Recognizing Distinct Epitopes and Forms of SOD1
por: Broering, Teresa J., et al.
Publicado: (2013)

Evidence of Compromised Blood-Spinal Cord Barrier in Early and Late Symptomatic SOD1 Mice Modeling ALS
por: Garbuzova-Davis, Svitlana, et al.
Publicado: (2007)

Intranasally Applied Neuropeptide S Shifts a High-Anxiety Electrophysiological Endophenotype in the Ventral Hippocampus towards a "Normal"-Anxiety One
por: Dine, Julien, et al.
Publicado: (2015)

Superoxide Dismutase Gene (SOD1, SOD2, and SOD3) Polymorphisms and Antituberculosis Drug-induced Hepatitis
por: Kim, Sang-Hoon, et al.
Publicado: (2015)

Using Gelatin Nanoparticle Mediated Intranasal Delivery of Neuropeptide Substance P to Enhance Neuro-Recovery in Hemiparkinsonian Rats
por: Zhao, Ying-Zheng, et al.
Publicado: (2016)

Intranasal Neuropeptide Y as a Potential Therapeutic for Depressive Behavior in the Rodent Single Prolonged Stress Model in Females
por: Nahvi, Roxanna J., et al.
Publicado: (2021)

Spinal cord pathology is ameliorated by P2X7 antagonism in a SOD1-mutant mouse model of amyotrophic lateral sclerosis
por: Apolloni, Savina, et al.
Publicado: (2014)

Analysis of Serum Cytokines and Single-Nucleotide Polymorphisms of SOD1, SOD2, and CAT in Erysipelas Patients
por: Emene, Charles C., et al.
Publicado: (2017)

Polymorphisms in the Mn-SOD and EC-SOD Genes and Their Relationship to Diabetic Neuropathy in Type 1 Diabetes Mellitus
por: Chistyakov, Dimitry A, et al.
Publicado: (2001)

Ligand binding and aggregation of pathogenic SOD1
por: Wright, Gareth S.A., et al.
Publicado: (2013)

Features of wild-type human SOD1 limit interactions with misfolded aggregates of mouse G86R Sod1
por: Qualls, David A, et al.
Publicado: (2013)

A novel SOD1-ALS mutation separates central and peripheral effects of mutant SOD1 toxicity
por: Joyce, Peter I., et al.
Publicado: (2015)

An examination of wild-type SOD1 in modulating the toxicity and aggregation of ALS-associated mutant SOD1
por: Prudencio, Mercedes, et al.
Publicado: (2010)

Nodularin Exposure Induces SOD1 Phosphorylation and Disrupts SOD1 Co-localization with Actin Filaments
por: Hjørnevik, Linda V., et al.
Publicado: (2012)

PT652. Neuropeptide receptor genes polymorphism and sleep disorders
por: Gafarov, V.V., et al.
Publicado: (2016)

Another de novo mutation in the SOD1 gene: the first Turkish patient with SOD1-His47Arg, a case report
por: Bayraktar, Elif, et al.
Publicado: (2023)

Adherent Monomer-Misfolded SOD1
por: Watanabe, Yasuhiro, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_gbthh6cml9athrams18kc5t21k