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Optimizing the balance between heterologous acetate- and CO(2)-reduction pathways in anaerobic cultures of Saccharomyces cerevisiae strains engineered for low-glycerol production

In anaerobic Saccharomyces cerevisiae cultures, NADH (reduced form of nicotinamide adenine dinucleotide)-cofactor balancing by glycerol formation constrains ethanol yields. Introduction of an acetate-to-ethanol reduction pathway based on heterologous acetylating acetaldehyde dehydrogenase (A-ALD) ca...

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Detalles Bibliográficos
Autores principales: van Aalst, Aafke C A, Geraats, Ellen H, Jansen, Mickel L A, Mans, Robert, Pronk, Jack T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647013/
https://www.ncbi.nlm.nih.gov/pubmed/37942589
http://dx.doi.org/10.1093/femsyr/foad048