Cargando…

Distinct transcriptional responses to fludioxonil in Aspergillus fumigatus and its ΔtcsC and Δskn7 mutants reveal a crucial role for Skn7 in the cell wall reorganizations triggered by this antifungal

BACKGROUND: Aspergillus fumigatus is a major fungal pathogen that causes severe problems due to its increasing resistance to many therapeutic agents. Fludioxonil is a compound that triggers a lethal activation of the fungal-specific High Osmolarity Glycerol pathway. Its pronounced antifungal activit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schruefer, Sebastian, Pschibul, Annica, Wong, Sarah Sze Wah, Sae-Ong, Tongta, Wolf, Thomas, Schäuble, Sascha, Panagiotou, Gianni, Brakhage, Axel A., Aimanianda, Vishukumar, Kniemeyer, Olaf, Ebel, Frank
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647056/ https://www.ncbi.nlm.nih.gov/pubmed/37964194 http://dx.doi.org/10.1186/s12864-023-09777-5

Ejemplares similares

The response regulator Skn7 of Aspergillus fumigatus is essential for the antifungal effect of fludioxonil
por: Schruefer, Sebastian, et al.
Publicado: (2021)

The Two-Component Sensor Kinase TcsC and Its Role in Stress Resistance of the Human-Pathogenic Mold Aspergillus fumigatus
por: McCormick, Allison, et al.
Publicado: (2012)

Ypd1 Is an Essential Protein of the Major Fungal Pathogen Aspergillus fumigatus and a Key Element in the Phosphorelay That Is Targeted by the Antifungal Drug Fludioxonil
por: Schruefer, Sebastian, et al.
Publicado: (2021)

Phenotypic and Proteomic Analysis of the Aspergillus fumigatus ΔPrtT, ΔXprG and ΔXprG/ΔPrtT Protease-Deficient Mutants
por: Shemesh, Einav, et al.
Publicado: (2017)

NikA/TcsC Histidine Kinase Is Involved in Conidiation, Hyphal Morphology, and Responses to Osmotic Stress and Antifungal Chemicals in Aspergillus fumigatus
por: Hagiwara, Daisuke, et al.
Publicado: (2013)

Saccharomyces cerevisiae cells lacking transcription factors Skn7 or Yap1 exhibit different susceptibility to cyanidin
por: Ruta, Lavinia Liliana, et al.
Publicado: (2020)

Humoral Immunity Against Aspergillus fumigatus
por: Dellière, Sarah, et al.
Publicado: (2023)

SKN-1/Nrf, A New Unfolded Protein Response Factor?
por: Choe, Keith P., et al.
Publicado: (2013)

SKN-1 regulates stress resistance downstream of amino catabolism pathways
por: Frankino, Phillip A., et al.
Publicado: (2022)

Comparative analysis of the molecular and physiological consequences of constitutive SKN-1 activation
por: Ramos, Carmen M., et al.
Publicado: (2023)

Complex regulation of Hsf1-Skn7 activities by the catalytic subunits of PKA in Saccharomyces cerevisiae: experimental and computational evidences
por: Pérez-Landero, Sergio, et al.
Publicado: (2015)

The Stress Response Regulator AflSkn7 Influences Morphological Development, Stress Response, and Pathogenicity in the Fungus Aspergillus flavus
por: Zhang, Feng, et al.
Publicado: (2016)

Role of ROX1, SKN7, and YAP6 Stress Transcription Factors in the Production of Secondary Metabolites in Xanthophyllomyces dendrorhous
por: Martínez-Moya, Pilar, et al.
Publicado: (2022)

Production of Extracellular Traps against Aspergillus fumigatus In Vitro and in Infected Lung Tissue Is Dependent on Invading Neutrophils and Influenced by Hydrophobin RodA
por: Bruns, Sandra, et al.
Publicado: (2010)

A Role for SKN-1/Nrf in Pathogen Resistance and Immunosenescence in Caenorhabditis elegans
por: Papp, Diána, et al.
Publicado: (2012)

Integration of the Unfolded Protein and Oxidative Stress Responses through SKN-1/Nrf
por: Glover-Cutter, Kira M., et al.
Publicado: (2013)

Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence
por: Steinbaugh, Michael J, et al.
Publicado: (2015)

Arginine methylation of SKN-1 promotes oxidative stress resistance in Caenorhabditis elegans
por: Li, Hongyuan, et al.
Publicado: (2019)

skn-1 is required for interneuron sensory integration and foraging behavior in Caenorhabditis elegans
por: Wilson, Mark A., et al.
Publicado: (2017)

The transcription factor SKN7 regulates conidiation, thermotolerance, apoptotic-like cell death and parasitism in the nematode endoparasitic fungus Hirsutella minnesotensis
por: Hussain, Muzammil, et al.
Publicado: (2016)

Specific SKN-1/Nrf Stress Responses to Perturbations in Translation Elongation and Proteasome Activity
por: Li, Xuan, et al.
Publicado: (2011)

HIF-1 and SKN-1 Coordinate the Transcriptional Response to Hydrogen Sulfide in Caenorhabditis elegans
por: Miller, Dana L., et al.
Publicado: (2011)

Isolation of a Hypomorphic skn-1 Allele That Does Not Require a Balancer for Maintenance
por: Tang, Lanlan, et al.
Publicado: (2015)

Redirection of SKN-1 abates the negative metabolic outcomes of a perceived pathogen infection
por: Nhan, James D., et al.
Publicado: (2019)

Temporal requirements of SKN-1/NRF as a regulator of lifespan and proteostasis in Caenorhabditis elegans
por: Grushko, Danielle, et al.
Publicado: (2021)

Tyrosine catabolites influence SKN-1 signaling in a model of Type I Tyrosinemia
por: Siddiqi, Talha F, et al.
Publicado: (2022)

Host Soluble Mediators: Defying the Immunological Inertness of Aspergillus fumigatus Conidia
por: Wong, Sarah Sze Wah, et al.
Publicado: (2017)

Trx2p-dependent Regulation of Saccharomyces cerevisiae Oxidative Stress Response by the Skn7p Transcription Factor under Respiring Conditions
por: Gómez-Pastor, Rocío, et al.
Publicado: (2013)

SKN-1 and Nrf2 couples proline catabolism with lipid metabolism during nutrient deprivation
por: Pang, Shanshan, et al.
Publicado: (2014)

Glucose negatively affects Nrf2/SKN-1-mediated innate immunity in C. elegans
por: Li, Le, et al.
Publicado: (2018)

O-GlcNAcylation of SKN-1 modulates the lifespan and oxidative stress resistance in Caenorhabditis elegans
por: Li, Hongyuan, et al.
Publicado: (2017)

SKN-1 Is a Negative Regulator of DAF-16 and Somatic Stress Resistance in Caenorhabditis elegans
por: Deng, Jianhui, et al.
Publicado: (2020)

ICD-1/BTF3 antagonizes SKN-1-mediated endoderm specification in Caenorhabditis elegans
por: Ewe, Chee Kiang, et al.
Publicado: (2019)

Neuronal SKN-1B modulates nutritional signalling pathways and mitochondrial networks to control satiety
por: Tataridas-Pallas, Nikolaos, et al.
Publicado: (2021)

The Conserved SKN-1/Nrf2 Stress Response Pathway Regulates Synaptic Function in Caenorhabditis elegans
por: Staab, Trisha A., et al.
Publicado: (2013)

Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1
por: Lehrbach, Nicolas J, et al.
Publicado: (2016)

The transcription factor SKN-1 and detoxification gene ugt-22 alter albendazole efficacy in Caenorhabditis elegans
por: Fontaine, Pauline, et al.
Publicado: (2018)

The activation of the oxidative stress response transcription factor SKN-1 in Caenorhabditis elegans by mitis group streptococci
por: Naji, Ali, et al.
Publicado: (2018)

Nuclear and cytoplasmic WDR-23 isoforms mediate differential effects on GEN-1 and SKN-1 substrates
por: Spatola, Brett N., et al.
Publicado: (2019)

Selenite Enhances Immune Response against Pseudomonas aeruginosa PA14 via SKN-1 in Caenorhabditis elegans
por: Li, Wen-Hsuan, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_v3nadj1r11s0p0vc5h47os7mns