The Complex Effects of PKM2 and PKM2:IP(3)R Disruption on Intracellular Ca(2+) Handling and Cellular Functions

Pyruvate kinase M (PKM) 2 was described to interact with the inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R) and suppress its activity. To further investigate the physiological importance of the PKM2:IP(3)R interaction, we developed and characterized HeLa PKM2 knockout (KO) cells. In the HeLa...

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Detalles Bibliográficos
Autores principales: Lemos, Fernanda O., de Ridder, Ian, Bootman, Martin D., Bultynck, Geert, Parys, Jan B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647343/
https://www.ncbi.nlm.nih.gov/pubmed/37947604
http://dx.doi.org/10.3390/cells12212527

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647343/
https://www.ncbi.nlm.nih.gov/pubmed/37947604
http://dx.doi.org/10.3390/cells12212527

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