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The Complex Effects of PKM2 and PKM2:IP(3)R Disruption on Intracellular Ca(2+) Handling and Cellular Functions
Pyruvate kinase M (PKM) 2 was described to interact with the inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R) and suppress its activity. To further investigate the physiological importance of the PKM2:IP(3)R interaction, we developed and characterized HeLa PKM2 knockout (KO) cells. In the HeLa...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647343/ https://www.ncbi.nlm.nih.gov/pubmed/37947604 http://dx.doi.org/10.3390/cells12212527 |