Cargando…

Improving the Biological Properties of Thrombin-Binding Aptamer by Incorporation of 8-Bromo-2′-Deoxyguanosine and 2′-Substituted RNA Analogues

Thrombin-binding aptamer (TBA) is one of the best-known G-quadruplex (G4)-forming aptamers. By adopting its peculiar chair-like G4 structure, TBA can efficiently bind to thrombin, thus producing an anticoagulant effect. The major limit to its therapeutic application is represented by its poor therma...

Descripción completa

Detalles Bibliográficos
Autores principales: Virgilio, Antonella, Benigno, Daniela, Aliberti, Carla, Vellecco, Valentina, Bucci, Mariarosaria, Esposito, Veronica, Galeone, Aldo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647374/
https://www.ncbi.nlm.nih.gov/pubmed/37958511
http://dx.doi.org/10.3390/ijms242115529