Improving the Biological Properties of Thrombin-Binding Aptamer by Incorporation of 8-Bromo-2′-Deoxyguanosine and 2′-Substituted RNA Analogues

Thrombin-binding aptamer (TBA) is one of the best-known G-quadruplex (G4)-forming aptamers. By adopting its peculiar chair-like G4 structure, TBA can efficiently bind to thrombin, thus producing an anticoagulant effect. The major limit to its therapeutic application is represented by its poor therma...

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Detalles Bibliográficos
Autores principales: Virgilio, Antonella, Benigno, Daniela, Aliberti, Carla, Vellecco, Valentina, Bucci, Mariarosaria, Esposito, Veronica, Galeone, Aldo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647374/
https://www.ncbi.nlm.nih.gov/pubmed/37958511
http://dx.doi.org/10.3390/ijms242115529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647374/
https://www.ncbi.nlm.nih.gov/pubmed/37958511
http://dx.doi.org/10.3390/ijms242115529

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