Cargando…

Oncogenic Gαq activates RhoJ through PDZ-RhoGEF

Oncogenic Gα(q) causes uveal melanoma via non-canonical signaling pathways. This constitutively active mutant GTPase is also found in cutaneous melanoma, lung adenocarcinoma, and seminoma, as well as in benign vascular tumors, such as congenital hemangiomas. We recently described that PDZ-RhoGEF (al...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cervantes-Villagrana, Rodolfo Daniel, Color-Aparicio, Víctor Manuel, Castillo-Kauil, Alejandro, García-Jiménez, Irving, Beltrán-Navarro, Yarely Mabell, Reyes-Cruz, Guadalupe, Vázquez-Prado, José
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647656/ https://www.ncbi.nlm.nih.gov/pubmed/37958718 http://dx.doi.org/10.3390/ijms242115734

Ejemplares similares

Gβγ mediates activation of Rho guanine nucleotide exchange factor ARHGEF17 that promotes metastatic lung cancer progression
por: García-Jiménez, Irving, et al.
Publicado: (2021)

Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission
por: Martz, Matthew K., et al.
Publicado: (2013)

PDZ-RhoGEF Is a Signaling Effector for TROY-Induced Glioblastoma Cell Invasion and Survival
por: Ding, Zonghui, et al.
Publicado: (2018)

PAK4 suppresses PDZ-RhoGEF activity to drive invadopodia maturation in melanoma cells
por: Nicholas, Nicole S., et al.
Publicado: (2016)

The Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetes
por: Chang, Ying-Ju, et al.
Publicado: (2015)

PDZ-RhoGEF ubiquitination by Cullin3–KLHL20 controls neurotrophin-induced neurite outgrowth
por: Lin, Mei-Yao, et al.
Publicado: (2011)

Rho GTPase–independent regulation of mitotic progression by the RhoGEF Net1
por: Menon, Sarita, et al.
Publicado: (2013)

Turning Platelets Off and On: Role of RhoGAPs and RhoGEFs in Platelet Activity
por: Comer, Shane P.
Publicado: (2022)

RHGF-2 Is an Essential Rho-1 Specific RhoGEF that binds to the Multi-PDZ Domain Scaffold Protein MPZ-1 in Caenorhabditis elegans
por: Lin, Li, et al.
Publicado: (2012)

Tension on JAM-A activates RhoA via GEF-H1 and p115 RhoGEF
por: Scott, David W., et al.
Publicado: (2016)

Prepatterning by RhoGEFs governs Rho GTPase spatiotemporal dynamics during wound repair
por: Nakamura, Mitsutoshi, et al.
Publicado: (2017)

The RhoGEF DOCK10 is essential for dendritic spine morphogenesis
por: Jaudon, Fanny, et al.
Publicado: (2015)

The Evolutionary Relationship of the Domain Architectures in the RhoGEF-containing Proteins
por: Sun, Qing-Lan, et al.
Publicado: (2005)

I’m coming to GEF you: Regulation of RhoGEFs during cell migration
por: Goicoechea, Silvia M, et al.
Publicado: (2014)

Rho GTPase RhoJ is Associated with Gastric Cancer Progression and Metastasis
por: Kim, Chan, et al.
Publicado: (2016)

Plasma membrane restricted RhoGEF activity is sufficient for RhoA-mediated actin polymerization
por: van Unen, Jakobus, et al.
Publicado: (2015)

p115RhoGEF activates RhoA to support tight junction maintenance and remodeling
por: Chumki, Shahana A., et al.
Publicado: (2022)

RhoGEF17—An Essential Regulator of Endothelial Cell Death and Growth
por: Weber, Pamina, et al.
Publicado: (2021)

The RGS-RhoGEFs control the amplitude of YAP1 activation by serum
por: Lane, Brandon S., et al.
Publicado: (2021)

Contributions of the RhoGEF activity of p210 BCR/ABL to disease progression
por: Tala, Ilona, et al.
Publicado: (2012)

A Novel Role for p115RhoGEF in Regulation of Epithelial Plasticity
por: Kher, Swapnil S., et al.
Publicado: (2014)

Characterization and computational simulation of human Syx, a RhoGEF implicated in glioblastoma
por: Boyd, Ryan J., et al.
Publicado: (2022)

Serine phosphorylation of the RhoGEF Trio stabilizes endothelial cell-cell junctions
por: Daniel, Anna E., et al.
Publicado: (2023)

Crystal structures of the PH domains from Lbc family of RhoGEFs bound to activated RhoA GTPase
por: Chen, Zhe, et al.
Publicado: (2018)

The Role of RhoJ in Endothelial Cell Biology and Tumor Pathology
por: Shi, Ting-Ting, et al.
Publicado: (2016)

Spatially restricted activation of RhoA at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis
por: Terry, Stephen J., et al.
Publicado: (2011)

Loss of the obscurin-RhoGEF downregulates RhoA signaling and increases microtentacle formation and attachment of breast epithelial cells
por: Perry, Nicole A., et al.
Publicado: (2014)

Snail-dependent repression of the RhoGEF pebble is required for gastrulation consistency in Drosophila melanogaster
por: Murray, Michael J., et al.
Publicado: (2012)

The RhoGEF TEM4 Regulates Endothelial Cell Migration by Suppressing Actomyosin Contractility
por: Mitin, Natalia, et al.
Publicado: (2013)

Plasma Membrane Association but Not Midzone Recruitment of RhoGEF ECT2 Is Essential for Cytokinesis
por: Kotýnková, Kristýna, et al.
Publicado: (2016)

The COOH-terminal domain of huntingtin interacts with RhoGEF kalirin and modulates cell survival
por: McClory, Hollis, et al.
Publicado: (2018)

Apical polarity proteins recruit the RhoGEF Cysts to promote junctional myosin assembly
por: Silver, Jordan T., et al.
Publicado: (2019)

The potential role of Arhgef33 RhoGEF in foveal development in the zebra finch retina
por: Sugiyama, Takefumi, et al.
Publicado: (2020)

Targeting the RhoGEF βPIX/COOL-1 in Glioblastoma: Proof of Concept Studies
por: Connor, Kate, et al.
Publicado: (2020)

The RhoGEF Trio: A Protein with a Wide Range of Functions in the Vascular Endothelium
por: Kempers, Lanette, et al.
Publicado: (2021)

Plexin-B1/RhoGEF–mediated RhoA activation involves the receptor tyrosine kinase ErbB-2
por: Swiercz, Jakub M., et al.
Publicado: (2004)

The Interplay between the Escherichia coli Rho Guanine Nucleotide Exchange Factor Effectors and the Mammalian RhoGEF Inhibitor EspH
por: Wong, Alexander R. C., et al.
Publicado: (2012)

Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF
por: Taya, Shinichiro, et al.
Publicado: (2001)

P115 RhoGEF and microtubules decide the direction apoptotic cells extrude from an epithelium
por: Slattum, Gloria, et al.
Publicado: (2009)

The RhoGEF Trio Functions in Sculpting Class Specific Dendrite Morphogenesis in Drosophila Sensory Neurons
por: Iyer, Srividya Chandramouli, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_201dic1krtsh3npj5tdj5bc3c5