New Thiazolyl-Pyrazoline Derivatives as Potential Dual EGFR/HER2 Inhibitors: Design, Synthesis, Anticancer Activity Evaluation and In Silico Study

A new series of thiazolyl-pyrazoline derivatives (4a–d, 5a–d 6a, b, 7a–d, 8a, b, and 10a, b) have been designed and synthesized through the combination of thiazole and pyrazoline moieties, starting from the key building blocks pyrazoline carbothioamides (1a–b). These eighteen derivatives have been d...

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Detalles Bibliográficos
Autores principales: Fakhry, Mariam M., Mattar, Amr A., Alsulaimany, Marwa, Al-Olayan, Ebtesam M., Al-Rashood, Sara T., Abdel-Aziz, Hatem A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647861/
https://www.ncbi.nlm.nih.gov/pubmed/37959874
http://dx.doi.org/10.3390/molecules28217455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647861/
https://www.ncbi.nlm.nih.gov/pubmed/37959874
http://dx.doi.org/10.3390/molecules28217455

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