Cargando…

New Thiazolyl-Pyrazoline Derivatives as Potential Dual EGFR/HER2 Inhibitors: Design, Synthesis, Anticancer Activity Evaluation and In Silico Study

A new series of thiazolyl-pyrazoline derivatives (4a–d, 5a–d 6a, b, 7a–d, 8a, b, and 10a, b) have been designed and synthesized through the combination of thiazole and pyrazoline moieties, starting from the key building blocks pyrazoline carbothioamides (1a–b). These eighteen derivatives have been d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fakhry, Mariam M., Mattar, Amr A., Alsulaimany, Marwa, Al-Olayan, Ebtesam M., Al-Rashood, Sara T., Abdel-Aziz, Hatem A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647861/ https://www.ncbi.nlm.nih.gov/pubmed/37959874 http://dx.doi.org/10.3390/molecules28217455

Ejemplares similares

Development of novel isatin thiazolyl-pyrazoline hybrids as promising antimicrobials in MDR pathogens
por: Al-Warhi, Tarfah, et al.
Publicado: (2022)

Discovery of novel thiazolyl-pyrazolines as dual EGFR and VEGFR-2 inhibitors endowed with in vitro antitumor activity towards non-small lung cancer
por: Abdelsalam, Esraa A., et al.
Publicado: (2022)

Synthesis, Biological Evaluation and 2D-QSAR Study of Halophenyl Bis-Hydrazones as Antimicrobial and Antitubercular Agents
por: Abdel-Aziz, Hatem A., et al.
Publicado: (2015)

Synthesis and Evaluation of New Pyrazoline Derivatives as Potential Anticancer Agents
por: Karabacak, Muhammed, et al.
Publicado: (2015)

Pyrazoline Hybrids as Promising Anticancer Agents: An Up-to-Date Overview
por: Matiadis, Dimitris, et al.
Publicado: (2020)

Design, Synthesis, Antiproliferative Actions, and DFT Studies of New Bis–Pyrazoline Derivatives as Dual EGFR/BRAF(V600E) Inhibitors
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

Synthesis, In Vitro Evaluation and Molecular Docking Studies of Novel Thiophenyl Thiazolyl-Pyridine Hybrids as Potential Anticancer Agents
por: Ashmawy, Fayza O., et al.
Publicado: (2023)

Thiazolo[3,2-a]benzimidazoles: Synthetic Strategies, Chemical Transformations and Biological Activities
por: Al-Rashood, Khalid A., et al.
Publicado: (2010)

Study of the Relationships between the Structure, Lipophilicity and Biological Activity of Some Thiazolyl-carbonyl-thiosemicarbazides and Thiazolyl-azoles
por: Tamaian, Radu, et al.
Publicado: (2015)

Synthesis and in Vitro Evaluation of New Nitro-Substituted Thiazolyl Hydrazone Derivatives as Anticandidal and Anticancer Agents
por: Altıntop, Mehlika Dilek, et al.
Publicado: (2014)

Design, efficient synthesis and molecular docking of some novel thiazolyl-pyrazole derivatives as anticancer agents
por: Sayed, Abdelwahed R., et al.
Publicado: (2019)

Synthesis, biological evaluation, and in silico studies of novel chalcone- and pyrazoline-based 1,3,5-triazines as potential anticancer agents
por: Moreno, Leydi M., et al.
Publicado: (2020)

Rational Design, Synthesis and Biological Evaluation of Novel Pyrazoline-Based Antiproliferative Agents in MCF-7 Cancer Cells
por: Fakhry, Mariam M., et al.
Publicado: (2022)

Synthesis and in vitro anticancer activity of certain novel 1-(2-methyl-6-arylpyridin-3-yl)-3-phenylureas as apoptosis-inducing agents
por: Eldehna, Wagdy M., et al.
Publicado: (2019)

Design, Synthesis, and Biological Evaluation of Novel 3-Cyanopyridone/Pyrazoline Hybrids as Potential Apoptotic Antiproliferative Agents Targeting EGFR/BRAF(V600E) Inhibitory Pathways
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

Synthesis, Biological Evaluation and In Silico Studies of Certain Oxindole–Indole Conjugates as Anticancer CDK Inhibitors
por: Al-Warhi, Tarfah, et al.
Publicado: (2020)

Coumarin–carbazole based functionalized pyrazolines: synthesis, characterization, anticancer investigation and molecular docking
por: Patel, Mrugesh, et al.
Publicado: (2021)

Synthesis, Characterization and Molecular Docking of Novel Bioactive Thiazolyl-Thiazole Derivatives as Promising Cytotoxic Antitumor Drug
por: Gomha, Sobhi M., et al.
Publicado: (2015)

Novel piperazine–chalcone hybrids and related pyrazoline analogues targeting VEGFR-2 kinase; design, synthesis, molecular docking studies, and anticancer evaluation
por: Ahmed, Marwa F., et al.
Publicado: (2020)

Synthesis of New 1,3,5-Triazine-Based 2-Pyrazolines as Potential Anticancer Agents
por: Moreno, Leydi M., et al.
Publicado: (2018)

Kallolide A acetate pyrazoline
por: Rodríguez-Escudero, Idaliz, et al.
Publicado: (2011)

Biological evaluation, docking studies, and in silico ADME prediction of some pyrimidine and pyridine derivatives as potential EGFR(WT) and EGFR(T790M) inhibitors
por: Al-Warhi, Tarfah, et al.
Publicado: (2022)

Synthesis and Antiproliferative Activity of Thiazolyl-bis-pyrrolo[2,3-b]pyridines and Indolyl-thiazolyl-pyrrolo[2,3-c]pyridines, Nortopsentin Analogues
por: Carbone, Anna, et al.
Publicado: (2015)

Synthesis and Anticancer Activity of Some Novel Tetralin-6-yl-pyrazoline, 2-Thioxopyrimidine, 2-Oxopyridine, 2-Thioxo-pyridine and 2-Iminopyridine Derivatives
por: Al-Abdullah, Ebtehal S.
Publicado: (2011)

Synthesis of Oxadiazolyl, Pyrazolyl and Thiazolyl Derivatives of Thiophene-2-Carboxamide as Antimicrobial and Anti-HCV Agents
por: Rizk, Ola H., et al.
Publicado: (2017)

Synthesis and Evaluation of New Pyrazoline Derivatives as Potential Anticancer Agents in HepG-2 Cell Line
por: Xu, Weijie, et al.
Publicado: (2017)

Design and efficient synthesis of pyrazoline and isoxazole bridged indole C-glycoside hybrids as potential anticancer agents
por: Kumari, Priti, et al.
Publicado: (2020)

Synthesis and In Vitro Anticancer Activity of Novel 4-Aryl-3-(4-methoxyphenyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridines Arrest Cell Cycle and Induce Cell Apoptosis by Inhibiting CDK2 and/or CDK9
por: Almansour, Basma S., et al.
Publicado: (2023)

Ethyl 1-(4-methylphenyl)-5-phenyl-4-phenylsulfonyl-1H-pyrazole-3-carboxylate
por: Abdel-Aziz, Hatem A., et al.
Publicado: (2011)

(Z)-1-(4-Methylphenyl)-2-(phenylsulfonyl)ethanone oxime
por: Fun, Hoong-Kun, et al.
Publicado: (2012)

Anticancer effect of Indanone-based thiazolyl hydrazone derivative on p53 mutant colorectal cancer cell lines: An in vitro and in vivo study
por: Narayanan, Silpa, et al.
Publicado: (2022)

Pyrazoles and Pyrazolines as Anti-Inflammatory Agents
por: Mantzanidou, Martha, et al.
Publicado: (2021)

New Anticancer Theobromine Derivative Targeting EGFR(WT) and EGFR(T790M): Design, Semi-Synthesis, In Silico, and In Vitro Anticancer Studies
por: Elkaeed, Eslam B., et al.
Publicado: (2022)

Microwave-assisted synthesis and antioxidant properties of hydrazinyl thiazolyl coumarin derivatives
por: Osman, Hasnah, et al.
Publicado: (2012)

Synthesis, lipophilicity and antimicrobial activity evaluation of some new thiazolyl-oxadiazolines
por: STOICA, CRISTINA IOANA, et al.
Publicado: (2015)

An Efficient Synthesis of Novel Bioactive Thiazolyl-Phthalazinediones under Ultrasound Irradiation
por: Elsharabasy, Fatma S., et al.
Publicado: (2017)

A New Series of Cytotoxic Pyrazoline Derivatives as Potential Anticancer Agents that Induce Cell Cycle Arrest and Apoptosis
por: Wang, Hong, et al.
Publicado: (2017)

Discovery of 3,6-disubstituted pyridazines as a novel class of anticancer agents targeting cyclin-dependent kinase 2: synthesis, biological evaluation and in silico insights
por: Sabt, Ahmed, et al.
Publicado: (2020)

Multifunctional Aspects of the Synthesized Pyrazoline Derivatives for AP1 5L X60 Steel Protection Against MIC and Acidization: Electrochemical, In Silico, and SRB Insights
por: Abbas, Mohamed A., et al.
Publicado: (2021)

5,6-Dimethyl-4-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-amine
por: Abdel-Aziz, Hatem A., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_u610e63nd5pjljc4rsnh7no6nq