Nanoparticles of a Pyrazolo-Pyridazine Derivative as Potential EGFR and CDK-2 Inhibitors: Design, Structure Determination, Anticancer Evaluation and In Silico Studies

The strategic planning of this study is based upon using the nanoformulation method to prepare nanoparticles 4-SLNs and 4-LPHNPs of the previously prepared 4,5-diphenyl-1H-pyrazolo[3,4-c]pyridazin-3-amine (4) after confirming its structure with single crystal X-ray analysis. These nanoparticles exhi...

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Detalles Bibliográficos
Autores principales: Hashem, Heba E., Amr, Abd El-Galil E., Almehizia, Abdulrahman A., Naglah, Ahmed M., Kariuki, Benson M., Eassa, Heba A., Nossier, Eman S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648062/
https://www.ncbi.nlm.nih.gov/pubmed/37959672
http://dx.doi.org/10.3390/molecules28217252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648062/
https://www.ncbi.nlm.nih.gov/pubmed/37959672
http://dx.doi.org/10.3390/molecules28217252

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