Down-Regulation of CYP3A4 by the K(Ca)1.1 Inhibition Is Responsible for Overcoming Resistance to Doxorubicin in Cancer Spheroid Models

The large-conductance Ca(2+)-activated K(+) channel, K(Ca)1.1, plays a pivotal role in cancer progression, metastasis, and the acquisition of chemoresistance. Previous studies indicated that the pharmacological inhibition of K(Ca)1.1 overcame resistance to doxorubicin (DOX) by down-regulating multid...

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Detalles Bibliográficos
Autores principales: Ohya, Susumu, Kajikuri, Junko, Kito, Hiroaki, Matsui, Miki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648085/
https://www.ncbi.nlm.nih.gov/pubmed/37958656
http://dx.doi.org/10.3390/ijms242115672

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648085/
https://www.ncbi.nlm.nih.gov/pubmed/37958656
http://dx.doi.org/10.3390/ijms242115672

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