Extracellular Hsp90 Binds to and Aligns Collagen-1 to Enhance Breast Cancer Cell Invasiveness

SIMPLE SUMMARY: Breast cancer cells secrete Hsp90, a protein that, inside of cells, regulates the function of hundreds of proteins, but outside of cells, extracellular Hsp90 (eHsp90) can activate a subset of proteins that promote invasion, the first step of metastasis. Blocking eHsp90 in mouse model...

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Detalles Bibliográficos
Autores principales: Singh, Pragya, Ramanathan, Varshini, Zhang, Yang, Georgakoudi, Irene, Jay, Daniel G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648158/
https://www.ncbi.nlm.nih.gov/pubmed/37958410
http://dx.doi.org/10.3390/cancers15215237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648158/
https://www.ncbi.nlm.nih.gov/pubmed/37958410
http://dx.doi.org/10.3390/cancers15215237

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