Discovery of Novel Biphenyl Carboxylic Acid Derivatives as Potent URAT1 Inhibitors

Urate transporter 1 (URAT1) is a clinically validated target for the treatment of hyperuricemia and gout. Due to the absence of protein structures, the molecular design of new URAT1 inhibitors generally resorts to ligand-based approaches. Two series of biphenyl carboxylic acids were designed based o...

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Detalles Bibliográficos
Autores principales: Hou, Xianxin, Wang, Yongcheng, Yang, Yajun, Xiao, Zhiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648204/
https://www.ncbi.nlm.nih.gov/pubmed/37959834
http://dx.doi.org/10.3390/molecules28217415

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648204/
https://www.ncbi.nlm.nih.gov/pubmed/37959834
http://dx.doi.org/10.3390/molecules28217415

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