Potential Modifying Effect of the APOEε4 Allele on Age of Onset and Clinical Manifestations in Patients with Early-Onset Alzheimer’s Disease with and without a Pathogenic Variant in PSEN1 in a Sample of the Mexican Population

In Alzheimer’s disease (AD), the age of onset (AoO) exhibits considerable variability, spanning from 40 to 90 years. Specifically, individuals diagnosed with AD and exhibiting symptoms prior to the age of 65 are typically classified as early onset (EOAD) cases. Notably, the apolipoprotein E (APOE) ε...

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Detalles Bibliográficos
Autores principales: Valdez-Gaxiola, César A., Maciel-Cruz, Eric Jonathan, Hernández-Peña, Rubiceli, Dumois-Petersen, Sofía, Rosales-Leycegui, Frida, Gallegos-Arreola, Martha Patricia, Moreno-Ortiz, José Miguel, Figuera, Luis E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648484/
https://www.ncbi.nlm.nih.gov/pubmed/37958671
http://dx.doi.org/10.3390/ijms242115687

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648484/
https://www.ncbi.nlm.nih.gov/pubmed/37958671
http://dx.doi.org/10.3390/ijms242115687

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