Physiologic and Transcriptomic Effects Triggered by Overexpression of Wild Type and Mutant DNA Topoisomerase I in Streptococcus pneumoniae

Topoisomerase I (TopoI) in Streptococcus pneumoniae, encoded by topA, is a suitable target for drug development. Seconeolitsine (SCN) is a new antibiotic that specifically blocks this enzyme. We obtained the topARA mutant, which encodes an enzyme less active than the wild type (topAWT) and more resi...

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Detalles Bibliográficos
Autores principales: García-López, Miriam, Hernández, Pablo, Megias, Diego, Ferrándiz, María-José, de la Campa, Adela G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648598/
https://www.ncbi.nlm.nih.gov/pubmed/37958782
http://dx.doi.org/10.3390/ijms242115800

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648598/
https://www.ncbi.nlm.nih.gov/pubmed/37958782
http://dx.doi.org/10.3390/ijms242115800

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