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Isolation and Identification of Chemical Compounds from Agaricus blazei Murrill and Their In Vitro Antifungal Activities
This study explores the antifungal properties of Agaricus blazei Murrill, a valuable medicinal and edible fungus. Six compounds (1–6) were first isolated from A. blazei using various isolation techniques and identified using spectroscopic methods. These compounds include linoleic acid, 1,1′-oxybis(2...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648600/ https://www.ncbi.nlm.nih.gov/pubmed/37959740 http://dx.doi.org/10.3390/molecules28217321 |
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author | Yu, Ruirui Li, Xiaojian Yi, Peng Wen, Ping Wang, Shuhong Liao, Chenghui Song, Xun Wu, Haiqiang He, Zhendan Li, Chenyang |
author_facet | Yu, Ruirui Li, Xiaojian Yi, Peng Wen, Ping Wang, Shuhong Liao, Chenghui Song, Xun Wu, Haiqiang He, Zhendan Li, Chenyang |
author_sort | Yu, Ruirui |
collection | PubMed |
description | This study explores the antifungal properties of Agaricus blazei Murrill, a valuable medicinal and edible fungus. Six compounds (1–6) were first isolated from A. blazei using various isolation techniques and identified using spectroscopic methods. These compounds include linoleic acid, 1,1′-oxybis(2,4-di-tert-butylbenzene), glycerol monolinoleate, volemolide (17R)-17-methylincisterol, (24s)-ergosta-7-en-3-ol, and dibutyl phthalate. This study also assesses the antifungal activities of these compounds against Trichophyton mentagrophology, Trichophyton rubrum, Candida albicans, and Cryptococcus neoformans. The results demonstrate varied sensitivities against these pathogenic fungi, with compound 2 showing significant inhibition against T. mentagrophology, compound 3 showing significant inhibition against T. rubrum, and compound 6 showing significant inhibition against C. albicans. This study underscores the medicinal potential of A. blazei as an antifungal agent and sheds light on its valuable research implications. |
format | Online Article Text |
id | pubmed-10648600 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106486002023-10-28 Isolation and Identification of Chemical Compounds from Agaricus blazei Murrill and Their In Vitro Antifungal Activities Yu, Ruirui Li, Xiaojian Yi, Peng Wen, Ping Wang, Shuhong Liao, Chenghui Song, Xun Wu, Haiqiang He, Zhendan Li, Chenyang Molecules Article This study explores the antifungal properties of Agaricus blazei Murrill, a valuable medicinal and edible fungus. Six compounds (1–6) were first isolated from A. blazei using various isolation techniques and identified using spectroscopic methods. These compounds include linoleic acid, 1,1′-oxybis(2,4-di-tert-butylbenzene), glycerol monolinoleate, volemolide (17R)-17-methylincisterol, (24s)-ergosta-7-en-3-ol, and dibutyl phthalate. This study also assesses the antifungal activities of these compounds against Trichophyton mentagrophology, Trichophyton rubrum, Candida albicans, and Cryptococcus neoformans. The results demonstrate varied sensitivities against these pathogenic fungi, with compound 2 showing significant inhibition against T. mentagrophology, compound 3 showing significant inhibition against T. rubrum, and compound 6 showing significant inhibition against C. albicans. This study underscores the medicinal potential of A. blazei as an antifungal agent and sheds light on its valuable research implications. MDPI 2023-10-28 /pmc/articles/PMC10648600/ /pubmed/37959740 http://dx.doi.org/10.3390/molecules28217321 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yu, Ruirui Li, Xiaojian Yi, Peng Wen, Ping Wang, Shuhong Liao, Chenghui Song, Xun Wu, Haiqiang He, Zhendan Li, Chenyang Isolation and Identification of Chemical Compounds from Agaricus blazei Murrill and Their In Vitro Antifungal Activities |
title | Isolation and Identification of Chemical Compounds from Agaricus blazei Murrill and Their In Vitro Antifungal Activities |
title_full | Isolation and Identification of Chemical Compounds from Agaricus blazei Murrill and Their In Vitro Antifungal Activities |
title_fullStr | Isolation and Identification of Chemical Compounds from Agaricus blazei Murrill and Their In Vitro Antifungal Activities |
title_full_unstemmed | Isolation and Identification of Chemical Compounds from Agaricus blazei Murrill and Their In Vitro Antifungal Activities |
title_short | Isolation and Identification of Chemical Compounds from Agaricus blazei Murrill and Their In Vitro Antifungal Activities |
title_sort | isolation and identification of chemical compounds from agaricus blazei murrill and their in vitro antifungal activities |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648600/ https://www.ncbi.nlm.nih.gov/pubmed/37959740 http://dx.doi.org/10.3390/molecules28217321 |
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