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Isolation and Identification of Chemical Compounds from Agaricus blazei Murrill and Their In Vitro Antifungal Activities

This study explores the antifungal properties of Agaricus blazei Murrill, a valuable medicinal and edible fungus. Six compounds (1–6) were first isolated from A. blazei using various isolation techniques and identified using spectroscopic methods. These compounds include linoleic acid, 1,1′-oxybis(2...

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Autores principales: Yu, Ruirui, Li, Xiaojian, Yi, Peng, Wen, Ping, Wang, Shuhong, Liao, Chenghui, Song, Xun, Wu, Haiqiang, He, Zhendan, Li, Chenyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648600/
https://www.ncbi.nlm.nih.gov/pubmed/37959740
http://dx.doi.org/10.3390/molecules28217321
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author Yu, Ruirui
Li, Xiaojian
Yi, Peng
Wen, Ping
Wang, Shuhong
Liao, Chenghui
Song, Xun
Wu, Haiqiang
He, Zhendan
Li, Chenyang
author_facet Yu, Ruirui
Li, Xiaojian
Yi, Peng
Wen, Ping
Wang, Shuhong
Liao, Chenghui
Song, Xun
Wu, Haiqiang
He, Zhendan
Li, Chenyang
author_sort Yu, Ruirui
collection PubMed
description This study explores the antifungal properties of Agaricus blazei Murrill, a valuable medicinal and edible fungus. Six compounds (1–6) were first isolated from A. blazei using various isolation techniques and identified using spectroscopic methods. These compounds include linoleic acid, 1,1′-oxybis(2,4-di-tert-butylbenzene), glycerol monolinoleate, volemolide (17R)-17-methylincisterol, (24s)-ergosta-7-en-3-ol, and dibutyl phthalate. This study also assesses the antifungal activities of these compounds against Trichophyton mentagrophology, Trichophyton rubrum, Candida albicans, and Cryptococcus neoformans. The results demonstrate varied sensitivities against these pathogenic fungi, with compound 2 showing significant inhibition against T. mentagrophology, compound 3 showing significant inhibition against T. rubrum, and compound 6 showing significant inhibition against C. albicans. This study underscores the medicinal potential of A. blazei as an antifungal agent and sheds light on its valuable research implications.
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spelling pubmed-106486002023-10-28 Isolation and Identification of Chemical Compounds from Agaricus blazei Murrill and Their In Vitro Antifungal Activities Yu, Ruirui Li, Xiaojian Yi, Peng Wen, Ping Wang, Shuhong Liao, Chenghui Song, Xun Wu, Haiqiang He, Zhendan Li, Chenyang Molecules Article This study explores the antifungal properties of Agaricus blazei Murrill, a valuable medicinal and edible fungus. Six compounds (1–6) were first isolated from A. blazei using various isolation techniques and identified using spectroscopic methods. These compounds include linoleic acid, 1,1′-oxybis(2,4-di-tert-butylbenzene), glycerol monolinoleate, volemolide (17R)-17-methylincisterol, (24s)-ergosta-7-en-3-ol, and dibutyl phthalate. This study also assesses the antifungal activities of these compounds against Trichophyton mentagrophology, Trichophyton rubrum, Candida albicans, and Cryptococcus neoformans. The results demonstrate varied sensitivities against these pathogenic fungi, with compound 2 showing significant inhibition against T. mentagrophology, compound 3 showing significant inhibition against T. rubrum, and compound 6 showing significant inhibition against C. albicans. This study underscores the medicinal potential of A. blazei as an antifungal agent and sheds light on its valuable research implications. MDPI 2023-10-28 /pmc/articles/PMC10648600/ /pubmed/37959740 http://dx.doi.org/10.3390/molecules28217321 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yu, Ruirui
Li, Xiaojian
Yi, Peng
Wen, Ping
Wang, Shuhong
Liao, Chenghui
Song, Xun
Wu, Haiqiang
He, Zhendan
Li, Chenyang
Isolation and Identification of Chemical Compounds from Agaricus blazei Murrill and Their In Vitro Antifungal Activities
title Isolation and Identification of Chemical Compounds from Agaricus blazei Murrill and Their In Vitro Antifungal Activities
title_full Isolation and Identification of Chemical Compounds from Agaricus blazei Murrill and Their In Vitro Antifungal Activities
title_fullStr Isolation and Identification of Chemical Compounds from Agaricus blazei Murrill and Their In Vitro Antifungal Activities
title_full_unstemmed Isolation and Identification of Chemical Compounds from Agaricus blazei Murrill and Their In Vitro Antifungal Activities
title_short Isolation and Identification of Chemical Compounds from Agaricus blazei Murrill and Their In Vitro Antifungal Activities
title_sort isolation and identification of chemical compounds from agaricus blazei murrill and their in vitro antifungal activities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648600/
https://www.ncbi.nlm.nih.gov/pubmed/37959740
http://dx.doi.org/10.3390/molecules28217321
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