Transmembrane Helices 7 and 8 Confer Aggregation Sensitivity to the Cystic Fibrosis Transmembrane Conductance Regulator

The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a large multi-spanning membrane protein that is susceptible to misfolding and aggregation. We have identified here the region responsible for this instability. Temperature-induced aggregation of C-terminally truncated versions of CFTR...

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Detalles Bibliográficos
Autores principales: Kleizen, Bertrand, de Mattos, Eduardo, Papaioannou, Olga, Monti, Michele, Tartaglia, Gian Gaetano, van der Sluijs, Peter, Braakman, Ineke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648718/
https://www.ncbi.nlm.nih.gov/pubmed/37958724
http://dx.doi.org/10.3390/ijms242115741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648718/
https://www.ncbi.nlm.nih.gov/pubmed/37958724
http://dx.doi.org/10.3390/ijms242115741

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