The critical role of arginine residues in the binding of human monoclonal antibodies to cardiolipin

Previously we reported that the variable heavy chain region (V(H)) of a human beta(2 )glycoprotein I-dependent monoclonal antiphospholipid antibody (IS4) was dominant in conferring the ability to bind cardiolipin (CL). In contrast, the identity of the paired variable light chain region (V(L)) determ...

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Detalles Bibliográficos
Autores principales: Giles, Ian, Lambrianides, Nancy, Latchman, David, Chen, Pojen, Chukwuocha, Reginald, Isenberg, David, Rahman, Anisur
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1064879/
https://www.ncbi.nlm.nih.gov/pubmed/15642142
http://dx.doi.org/10.1186/ar1449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1064879/
https://www.ncbi.nlm.nih.gov/pubmed/15642142
http://dx.doi.org/10.1186/ar1449

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