Cargando…

A phase I study of the safety, tolerability, and pharmacokinetics of contezolid acefosamil after intravenous and oral administration in healthy Chinese subjects

Contezolid acefosamil (also known as MRX-4), a prodrug of contezolid, is under development for treatment of multidrug-resistant Gram-positive bacterial infections. A phase I single ascending dose (SAD) and multiple-dose placebo-controlled study was conducted to assess the safety, tolerability, and p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Haijing, Jin, Yi, Wang, Hailin, Yuan, Hong, Wang, Jingjing, Li, Size, Hu, Yingying, Yang, Huahui, Li, Xin, Liang, Hong, Wu, Jufang, Cao, Guoying, Zhang, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648862/ https://www.ncbi.nlm.nih.gov/pubmed/37902402 http://dx.doi.org/10.1128/aac.00796-23

Ejemplares similares

1700. Efficacy and Safety in Subjects with Renal Impairment in Contezolid and Contezolid Acefosamil Phase 2 and Phase 3 Skin Infection Clinical Trials
por: Fang, Edward, et al.
Publicado: (2022)

1118. Population Pharmacokinetics of Contezolid Acefosamil and Contezolid – Rationale for a Safe and Effective Loading Dose Regimen
por: Bulitta, Jürgen B, et al.
Publicado: (2021)

Dose adjustment not required for contezolid in patients with moderate hepatic impairment based on pharmacokinetic/pharmacodynamic analysis
por: Wu, Junzhen, et al.
Publicado: (2023)

1701. Pharmacokinetics in Subjects with Renal Impairment in a Contezolid Complicated Skin and Soft Tissue Infection Phase 3 Clinical Trial
por: Fang, Edward, et al.
Publicado: (2022)

Safety, tolerability, pharmacokinetics, and immunogenicity of an anti-SARS-CoV-2 monoclonal antibody HFB30132A after single dose intravenous administration in healthy Chinese subjects: a phase 1, randomized, double-blind, placebo-controlled study
por: Li, Shanshan, et al.
Publicado: (2023)

2157. Phase 1 Study in Healthy Chinese Subjects of Novel Prodrug, MRX-4
por: Yang, Haijing, et al.
Publicado: (2023)

1702. Platelet Counts in Contezolid Complicated Skin and Soft Tissue Infection Phase 2 and Phase 3 Clinical Trials
por: Fang, Edward, et al.
Publicado: (2022)

Contezolid: First Approval
por: Hoy, Sheridan M.
Publicado: (2021)

Pharmacokinetic, Pharmacokinetic/Pharmacodynamic, and Safety Investigations of Lefamulin in Healthy Chinese Subjects
por: Hu, Yingying, et al.
Publicado: (2023)

Pharmacokinetics, Safety and Pharmacokinetics/Pharmacodynamics Analysis of Omadacycline in Chinese Healthy Subjects
por: Yang, Haijing, et al.
Publicado: (2022)

LZM008, a proposed tocilizumab biosimilar: Pharmacokinetics, safety, and immunogenicity profiles compared with ACTEMRA(®) in Chinese healthy male subjects
por: Cao, Guoying, et al.
Publicado: (2023)

Pharmacokinetics and tolerability of intranasal or intravenous administration of nalbuphine in infants
por: Pfiffner, Miriam, et al.
Publicado: (2023)

Clinical Utility of Contezolid-Containing Regimens in 25 Cases of Linezolid-Intolerable Tuberculosis Patients
por: Wang, Jun, et al.
Publicado: (2023)

A Randomized, Double‐Blind, Parallel‐Group, Phase 1 Clinical Trial Comparing the Pharmacokinetic, Safety, and Immunogenicity of the Biosimilar HS016 and the Originator Adalimumab in Chinese Healthy Male Subjects
por: Cao, Guoying, et al.
Publicado: (2020)

662. In vitro antibacterial activity of contezolid compared to linezolid and vancomycin in clinical isolates from China
por: Wang, Shanmei, et al.
Publicado: (2022)

Pharmacokinetics of Levornidazole Tablet in Healthy Chinese Subjects and Proposed Dosing Regimen Based on Pharmacokinetic/Pharmacodynamic Analysis
por: Wu, Hailan, et al.
Publicado: (2021)

A Novel Oxazolidinone, Contezolid (MRX-I), Expresses Anti-Mycobacterium abscessus Activity In Vitro
por: Guo, Qi, et al.
Publicado: (2021)

Pharmacokinetics of Danofloxacin in Gushi Chickens after Single Oral and Intravenous Administration
por: Chen, Jun-Cheng, et al.
Publicado: (2023)

Pharmacokinetics of meloxicam in pigeons after single intravenous, oral, and intramuscular administration
por: Chen, Jun-Cheng, et al.
Publicado: (2023)

Contezolid, a novel oxazolidinone antibiotic, may improve drug-related thrombocytopenia in clinical antibacterial treatment
por: Li, Bi, et al.
Publicado: (2023)

Antibacterial activity of the novel oxazolidinone contezolid (MRX-I) against Mycobacterium abscessus
por: Gao, Shan., et al.
Publicado: (2023)

In vitro activities of contezolid (MRX-I) against drug-sensitive and drug-resistant Mycobacterium tuberculosis
por: An, Huiru, et al.
Publicado: (2023)

Case report: Successful treatment with contezolid in a patient with tuberculous meningitis who was intolerant to linezolid
por: Xu, Zhe, et al.
Publicado: (2023)

Pharmacokinetics and Safety of Vedolizumab Following Administration of a Single Intravenous Dose in Healthy Chinese Subjects
por: Xie, Ran, et al.
Publicado: (2022)

Compassionate Use of Contezolid for the Treatment of Tuberculous Pleurisy in a Patient with a Leadless Pacemaker
por: Kang, Yixin, et al.
Publicado: (2022)

2710. Long Term Use of Contezolid in Lung Transplant Recipients Infected with Nocardia Species
por: Ju, Chunrong
Publicado: (2023)

Use of Contezolid for the Treatment of Refractory Infective Endocarditis in a Patient with Chronic Renal Failure: Case Report
por: Zhao, Sheng, et al.
Publicado: (2023)

Pharmacokinetics of BMEDA after Intravenous Administration in Beagle Dogs
por: Chang, Chih-Hsien, et al.
Publicado: (2014)

Pharmacokinetics of menbutone after intravenous and intramuscular administration to sheep
por: Diez, Raquel, et al.
Publicado: (2022)

Pharmacokinetics and tolerability of lefamulin following intravenous and oral dosing
por: Wicha, Wolfgang W, et al.
Publicado: (2019)

Safety, Tolerability and Pharmacokinetics of Single and Multiple Doses of Mirogabalin in Healthy Chinese Participants: A Randomized, Double-Blind, Placebo-Controlled Study
por: Li, Yi, et al.
Publicado: (2023)

Pharmacokinetic and Bioavailability Studies of Embelin after Intravenous and Oral Administration to Rats
por: Li, Zhen, et al.
Publicado: (2019)

The Pharmacokinetics of Doxycycline in Channel Catfish (Ictalurus punctatus) Following Intravenous and Oral Administrations
por: Xu, Ning, et al.
Publicado: (2020)

Pharmacokinetics, Safety, and Tolerability of Intravenous Durlobactam and Sulbactam in Subjects with Renal Impairment and Healthy Matched Control Subjects
por: O’Donnell, John, et al.
Publicado: (2019)

Pharmacokinetics and Safety of Doripenem in Healthy Chinese Subjects and Monte Carlo Dosing Simulations
por: Wang, Yu, et al.
Publicado: (2022)

Pharmacokinetics and bioavailability of chromium malate and its influence on trace metals absorption after oral or intravenous administration
por: Feng, Weiwei, et al.
Publicado: (2018)

Pharmacokinetics of morphine and oxycodone following intravenous administration in elderly patients
por: Villesen, Hanne H, et al.
Publicado: (2007)

Pharmacokinetics of cytisine after single intravenous and oral administration in rabbits
por: Astroug, Henri, et al.
Publicado: (2010)

Pharmacokinetics of Uridine Following Ocular, Oral and Intravenous Administration in Rabbits
por: Kim, Eunyoung, et al.
Publicado: (2013)

Posaconazole Pharmacokinetics in Healthy Cats after Oral and Intravenous Administration
por: Mawby, D.I., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_2du346s8rjkeoq40i6cpdhn032