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Tumor necrosis factor alpha and epidermal growth factor act additively to inhibit matrix gene expression by chondrocyte
The failure of chondrocytes to replace the lost extracellular matrix contributes to the progression of degenerative disorders of cartilage. Inflammatory mediators present in the joint regulate the breakdown of the established matrix and the synthesis of new extracellular matrix molecules. In the pre...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2005
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1064891/ https://www.ncbi.nlm.nih.gov/pubmed/15642133 http://dx.doi.org/10.1186/ar1464 |