Drug distribution and efficacy of the DprE1 inhibitor BTZ-043 in the C3HeB/FeJ mouse tuberculosis model

BTZ-043, a suicide inhibitor of the Mycobacterium tuberculosis cell wall synthesis decaprenylphosphoryl-beta-D-ribose 2′ epimerase, is under clinical development as a potential new anti-tuberculosis agent. BTZ-043 is potent and bactericidal in vitro but has limited activity against non-growing bacil...

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Detalles Bibliográficos
Autores principales: Ramey, Michelle E., Kaya, Firat, Bauman, Allison A., Massoudi, Lisa M., Sarathy, Jansy P., Zimmerman, Matthew D., Scott, Dashick W. L., Job, Alyx M., Miller-Dawson, Jake A., Podell, Brendan K., Lyons, Michael A., Dartois, Véronique, Lenaerts, Anne J., Robertson, Gregory T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648937/
https://www.ncbi.nlm.nih.gov/pubmed/37791784
http://dx.doi.org/10.1128/aac.00597-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648937/
https://www.ncbi.nlm.nih.gov/pubmed/37791784
http://dx.doi.org/10.1128/aac.00597-23

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