The cytochrome P450 reductase CprA is a rate-limiting factor for Cyp51A-mediated azole resistance in Aspergillus fumigatus

Azole antifungals remain the “gold standard” therapy for invasive aspergillosis. The world-wide emergence of isolates resistant to this drug class, however, developed into a steadily increasing threat to human health over the past years. In Aspergillus fumigatus, major mechanisms of resistance invol...

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Detalles Bibliográficos
Autores principales: Kühbacher, Alexander, Merschak, Petra, Haas, Hubertus, Liebl, Maximilian, Müller, Christoph, Gsaller, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648939/
https://www.ncbi.nlm.nih.gov/pubmed/37815358
http://dx.doi.org/10.1128/aac.00918-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648939/
https://www.ncbi.nlm.nih.gov/pubmed/37815358
http://dx.doi.org/10.1128/aac.00918-23

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