Fumagillin inhibits growth of the enteric protozoan parasite Entamoeba histolytica by covalently binding to and selectively inhibiting methionine aminopeptidase 2

Amebiasis is an important cause of morbidity and mortality worldwide, and caused by infection with the protozoan parasite Entamoeba histolytica. Metronidazole is currently the first-line drug despite adverse effects and concerns on the emergence of drug resistance. Fumagillin, a fungal metabolite fr...

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Detalles Bibliográficos
Autores principales: Watanabe, Natsuki, Saito-Nakano, Yumiko, Kurisawa, Naoaki, Otomo, Keisuke, Suenaga, Kiyotake, Nakano, Kentaro, Nozaki, Tomoyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Biologic Response Modifiers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648944/
https://www.ncbi.nlm.nih.gov/pubmed/37874291
http://dx.doi.org/10.1128/aac.00560-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648944/
https://www.ncbi.nlm.nih.gov/pubmed/37874291
http://dx.doi.org/10.1128/aac.00560-23

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