Cargando…

Fumagillin inhibits growth of the enteric protozoan parasite Entamoeba histolytica by covalently binding to and selectively inhibiting methionine aminopeptidase 2

Amebiasis is an important cause of morbidity and mortality worldwide, and caused by infection with the protozoan parasite Entamoeba histolytica. Metronidazole is currently the first-line drug despite adverse effects and concerns on the emergence of drug resistance. Fumagillin, a fungal metabolite fr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Watanabe, Natsuki, Saito-Nakano, Yumiko, Kurisawa, Naoaki, Otomo, Keisuke, Suenaga, Kiyotake, Nakano, Kentaro, Nozaki, Tomoyoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Biologic Response Modifiers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648944/ https://www.ncbi.nlm.nih.gov/pubmed/37874291 http://dx.doi.org/10.1128/aac.00560-23

Ejemplares similares

Endoplasmic reticulum‐resident Rab8A GTPase is involved in phagocytosis in the protozoan parasite Entamoeba histolytica
por: Hanadate, Yuki, et al.
Publicado: (2016)

Rab7D small GTPase is involved in phago‐, trogocytosis and cytoskeletal reorganization in the enteric protozoan Entamoeba histolytica
por: Saito‐Nakano, Yumiko, et al.
Publicado: (2020)

Pentoxifylline Alone or in Combination with Gentamicin or Vancomycin Inhibits Live Microbe-Induced Proinflammatory Cytokine Production in Human Cord Blood and Cord Blood Monocytes In Vitro
por: Speer, Esther M., et al.
Publicado: (2018)

PTEN differentially regulates endocytosis, migration, and proliferation in the enteric protozoan parasite Entamoeba histolytica
por: Kadri, Samia, et al.
Publicado: (2022)

Near-chromosome level genome assembly reveals ploidy diversity and plasticity in the intestinal protozoan parasite Entamoeba histolytica
por: Kawano-Sugaya, Tetsuro, et al.
Publicado: (2020)

Proteomic analysis of Atg8-dependent recruitment of phagosomal proteins in the enteric protozoan parasite Entamoeba histolytica
por: Nakada-Tsukui, Kumiko, et al.
Publicado: (2022)

ArfX2 GTPase Regulates Trafficking From the Trans-Golgi to Lysosomes and Is Necessary for Liver Abscess Formation in the Protozoan Parasite Entamoeba histolytica
por: Saito-Nakano, Yumiko, et al.
Publicado: (2021)

Corrigendum: ArfX2 GTPase Regulates Trafficking From the Trans-Golgi to Lysosomes and Is Necessary for Liver Abscess Formation in the Protozoan Parasite Entamoeba histolytica
por: Saito-Nakano, Yumiko, et al.
Publicado: (2022)

Chemogenomic Profiling of the Fungal Pathogen Candida albicans
por: Chen, Yaolin, et al.
Publicado: (2018)

Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria
por: Subramaniam, Suvitha, et al.
Publicado: (2018)

Treatment with Fluticasone Propionate Increases Antibiotic Efficacy during Treatment of Late-Stage Primary Pneumonic Plague
por: Crane, Samantha D., et al.
Publicado: (2022)

The Azithromycin Pro-Drug CSY5669 Boosts Bacterial Killing While Attenuating Lung Inflammation Associated with Pneumonia Caused by Methicillin-Resistant Staphylococcus aureus
por: Saris, Anno, et al.
Publicado: (2022)

The Cell Surface Proteome of Entamoeba histolytica
por: Biller, Laura, et al.
Publicado: (2014)

Phosphatidylinositol Kinases and Phosphatases in Entamoeba histolytica
por: Nakada-Tsukui, Kumiko, et al.
Publicado: (2019)

Dramatic Increase in Glycerol Biosynthesis upon Oxidative Stress in the Anaerobic Protozoan Parasite Entamoeba histolytica
por: Husain, Afzal, et al.
Publicado: (2012)

An Unusual U2AF2 Inhibits Splicing and Attenuates the Virulence of the Human Protozoan Parasite Entamoeba histolytica
por: González-Blanco, Gretter, et al.
Publicado: (2022)

Early Treatment with Fumagillin, an Inhibitor of Methionine Aminopeptidase-2, Prevents Pulmonary Hypertension in Monocrotaline-Injured Rats
por: Kass, Daniel J., et al.
Publicado: (2012)

Molecular Dissection of Phagocytosis by Proteomic Analysis in Entamoeba histolytica
por: Watanabe, Natsuki, et al.
Publicado: (2023)

Novel Transmembrane Receptor Involved in Phagosome Transport of Lysozymes and β-Hexosaminidase in the Enteric Protozoan Entamoeba histolytica
por: Furukawa, Atsushi, et al.
Publicado: (2012)

Identification and Characterization of the Entamoeba Histolytica Rab8a Binding Protein: A Cdc50 Homolog
por: Hanadate, Yuki, et al.
Publicado: (2018)

Global analysis of gene expression in response to L-Cysteine deprivation in the anaerobic protozoan parasite Entamoeba histolytica
por: Husain, Afzal, et al.
Publicado: (2011)

Small GTPase Rab21 Mediates Fibronectin Induced Actin Reorganization in Entamoeba histolytica: Implications in Pathogen Invasion
por: Emmanuel, Merlyn, et al.
Publicado: (2015)

Genetic, metabolomic and transcriptomic analyses of the de novo L-cysteine biosynthetic pathway in the enteric protozoan parasite Entamoeba histolytica
por: Jeelani, Ghulam, et al.
Publicado: (2017)

Sulfonamide Inhibition Studies of a New β-Carbonic Anhydrase from the Pathogenic Protozoan Entamoeba histolytica
por: Bua, Silvia, et al.
Publicado: (2018)

Trichostatin A effects on gene expression in the protozoan parasite Entamoeba histolytica
por: Ehrenkaufer, Gretchen M, et al.
Publicado: (2007)

Mass Spectrometric Analysis of l-Cysteine Metabolism: Physiological Role and Fate of l-Cysteine in the Enteric Protozoan Parasite Entamoeba histolytica
por: Jeelani, Ghulam, et al.
Publicado: (2014)

Cloning, Characterization and Anion Inhibition Studies of a β-Carbonic Anhydrase from the Pathogenic Protozoan Entamoeba histolytica
por: Haapanen, Susanna, et al.
Publicado: (2018)

Glycerol biosynthetic pathway plays an essential role in proliferation and antioxidative defense in the human enteric protozoan parasite Entamoeba histolytica
por: Jeelani, Ghulam, et al.
Publicado: (2023)

Role of the Gut Microbiota of Children in Diarrhea Due to the Protozoan Parasite Entamoeba histolytica
por: Gilchrist, Carol A., et al.
Publicado: (2016)

Postsplicing-Derived Full-Length Intron Circles in the Protozoan Parasite Entamoeba histolytica
por: Mendoza-Figueroa, María S., et al.
Publicado: (2018)

Identification of the phospholipid lysobisphosphatidic acid in the protozoan Entamoeba histolytica: An active molecule in endocytosis
por: Castellanos-Castro, Silvia, et al.
Publicado: (2015)

The NF-κB Pathway: Modulation by Entamoeba histolytica and Other Protozoan Parasites
por: Chadha, Attinder, et al.
Publicado: (2021)

Gasdermins in Innate Host Defense Against Entamoeba histolytica and Other Protozoan Parasites
por: Wang, Shanshan, et al.
Publicado: (2022)

Dynamism of PI4-Phosphate during Interactions with Human Erythrocytes in Entamoeba histolytica
por: Watanabe, Natsuki, et al.
Publicado: (2020)

Trend of Entamoeba histolytica infestation in Kolkata
por: Mukherjee, Avik K, et al.
Publicado: (2010)

Comparative Pathobiology of the Intestinal Protozoan Parasites Giardia lamblia, Entamoeba histolytica, and Cryptosporidium parvum
por: Hemphill, Andrew, et al.
Publicado: (2019)

Inhibiting Pyridoxal Kinase of Entamoeba histolytica Is Lethal for This Pathogen
por: Devi, Suneeta, et al.
Publicado: (2021)

Non-vesicular Lipid Transport Machinery in Entamoeba histolytica
por: Das, Koushik, et al.
Publicado: (2018)

Immune Response of Amebiasis and Immune Evasion by Entamoeba histolytica
por: Nakada-Tsukui, Kumiko, et al.
Publicado: (2016)

Gene expression of axenically-isolated clinical Entamoeba histolytica strains and its impact on disease severity of amebiasis
por: Yanagawa, Yasuaki, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_f30g3rd55g7pn7rdr3ko98kheu